Coordination of iron acquisition and heme synthesis is required for effective erythropoiesis. The small teleost zebrafish (Danio rerio) is an ideal vertebrate animal model to replicate various aspects of human physiology and provides an efficient and cost-effective way to model human pathophysiology. Importantly, zebrafish erythropoiesis largely resembles mammalian erythropoiesis. Gene discovery by large-scale forward mutagenesis screening has identified key components in heme and iron metabolism. Reverse genetic screens, using morpholino-knockdown and CRISPR/Cas9, coupled with the genetic tractability of the developing embryo have further accelerated functional studies. Ultimately, the ex utero development of zebrafish embryos combined with their transparency and developmental plasticity could provide a deeper understanding of the role of iron and heme metabolism during early vertebrate embryonic development.

中文翻译：

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斑马鱼作为模型系统来描述红细胞生成过程中血红素和铁代谢的作用。

有效的促红细胞生成需要铁的摄取和血红素合成的协调。小型硬骨斑马鱼（Danio rerio）是一种理想的脊椎动物模型，可以复制人类生理学的各个方面，并提供了一种有效且经济高效的方式来模拟人类病理生理学。重要的是，斑马鱼的红细胞生成很大程度上类似于哺乳动物的红细胞生成。通过大规模正向诱变筛选进行的基因发现已经确定了血红素和铁代谢中的关键成分。使用吗啉代敲除和CRISPR / Cas9进行反向遗传筛选，结合发育中的胚胎的遗传易处理性，进一步加速了功能研究。最终，