PURPOSE To compare regional variations in lamina cribrosa (LC) curvature and depth between healthy eyes (group 1) and naïve eyes with primary open-angle glaucoma (POAG) having superior (group 2), inferior (group 3), and both (group 4) hemifield retinal nerve fiber layer (RNFL) defects. DESIGN Cross-sectional study. PARTICIPANTS Each group consisted of 39 eyes of 39 Korean patients who were matched for age, sex, and axial length. METHODS The LC curvature index (LCCI) and LC depth (LCD) were measured in B-scan images obtained using enhanced depth imaging OCT at 7 locations spaced equidistantly across the vertical optic disc diameter. Superior and inferior LCCI and LCD were compared by calculating the superior-to-inferior (Sup/Inf) ratios. MAIN OUTCOME MEASURES Comparisons of LCCI, LCD, and Sup/Inf ratio among the 4 groups. RESULTS Compared with healthy eyes (group 1), LCCIs were larger at the superior and middle planes in group 2, at the inferior and middle planes in group 3, and at all planes in group 4 (P ≤ 0.003). The LCD showed similar results, but there was no difference in superior planes between groups 1 and 2. The Sup/Inf ratio of LCCI differed significantly between groups 1 (1.03) and 2 (1.20), groups 1 and 3 (0.79), groups 2 and 3, groups 2 and 4 (0.96), and groups 3 and 4 (all P < 0.001), but not between groups 1 and 4 (P = 0.273). The Sup/Inf ratio of LCD differed only between groups 2 and 3 (P = 0.002). CONCLUSIONS Eyes with POAG showed regional differences in LC morphology, corresponding with the location of RNFL defects. The regional variations in LCCI suggest that LC morphology in POAG would be better assessed on a regional basis than by a global index.

中文翻译：

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在朝鲜族人群中青光眼中有半球状缺陷的Lamina Cribrosa形态。

目的比较健康眼（第1组）和幼稚眼的原发性开角型青光眼（POAG）具有上眼（组2），下眼（组3）和两者（组）的筛网（LC）曲率和深度的区域变化4）半场视网膜神经纤维层（RNFL）缺损。设计横断面研究。参与者每组由39例韩国患者的39眼组成，这些患者的年龄，性别和眼轴长度均相匹配。方法在使用增强深度成像OCT在垂直视盘直径等距的7个位置获得的B扫描图像中，测量LC曲率指数（LCCI）和LC深度（LCD）。通过计算上下（Sup / Inf）比来比较上，下LCCI和LCD。主要观察指标4组之间LCCI，LCD和Sup / Inf比率的比较。结果与健康的眼睛（第1组）相比，第2组的上，中平面，第3组的下，中平面以及第4组的所有平面上的LCCI都更大（P≤0.003）。LCD显示相似的结果，但第1组和第2组之间的上平面没有差异。第1组（1.03）和第2组（1.20），第1和第3组（0.79），第1组之间LCCI的Sup / Inf比值有显着差异2和3，第2和第4组（0.96），第3和第4组（所有P <0.001），但不在第1和第4组之间（P = 0.273）。LCD的Sup / Inf比仅在第2组和第3组之间有所不同（P = 0.002）。结论POAG眼在LC形态上表现出区域差异，与RNFL缺损的位置相对应。