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Iridium-Catalyzed Asymmetric Allylic Substitution Reactions
Chemical Reviews ( IF 62.1 ) Pub Date : 2018-12-24 00:00:00 , DOI: 10.1021/acs.chemrev.8b00506
Qiang Cheng 1 , Hang-Fei Tu 1 , Chao Zheng 1 , Jian-Ping Qu 2 , Günter Helmchen 3 , Shu-Li You 1
Affiliation  

In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric allylic substitution reactions during the past two decades. Since the first report in 1997, Ir-catalyzed asymmetric allylic substitution reactions have attracted intense attention due to their exceptionally high regio- and enantioselectivities. Ir-catalyzed asymmetric allylic substitution reactions have been significantly developed in recent years in many respects, including ligand development, mechanistic understanding, substrate scope, and application in the synthesis of complex functional molecules. In this review, an explicit outline of ligands, mechanism, scope of nucleophiles, and applications is presented.

中文翻译:

铱催化的不对称烯丙基取代反应

在这篇综述中,我们总结了过去二十年来铱催化的不对称烯丙基取代反应的起源和进展。自1997年首次发表报告以来,由于Ir的非对称烯丙基取代反应具有极高的区域和对映选择性,因此受到了广泛的关注。近年来,Ir催化的不对称烯丙基取代反应已在许多方面得到了显着发展,包括配体开发,机理理解,底物范围以及在复杂功能分子合成中的应用。在这篇综述中,提出了配体,亲核试剂的范围,范围和应用的明确概述。
更新日期:2018-12-24
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