BACKGROUND Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. METHODS Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item Center for Epidemiologic Studies-Depression scale) with onset of mobility disability (a lot of difficulty or inability to walk ¼ mile and/or climb 10 steps) and any disability in activities of daily living (ADL), among 2,196 participants of the Health, Aging and Body Composition Study, a cohort of well-functioning older adults aged 70-79 years. Models were adjusted for age, race, sex, education, diabetes, hypertension, and body mass index. RESULTS Relative to participants with normal hearing and without depressive symptoms, participants without depressive symptoms who had mild or moderate/severe HL had increased risk of incident mobility and ADL disability (hazard ratio [HR] for mobility disability, mild HL:1.34, 95% confidence interval [CI]: 1.09, 1.64 and HR for mobility disability, moderate/severe HL: 1.37, 95% CI: 1.08, 1.75 and HR for ADL disability, mild HL: 1.32, 95% CI: 1.08, 1.63, and HR for ADL disability, moderate/severe HL: 1.42, 95% CI: 1.11, 1.82). Among participants with depressive symptoms, mild HL (HR: 1.71, 95% CI: 1.09, 2.70) was associated with increased risk of incident mobility disability. CONCLUSIONS Independent of depressive symptoms, risk of incident disability was greater in older adults with HL, regardless of severity. Further research into HL interventions may delay disability onset.

中文翻译：

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听力损失和抑郁症状与老年人事件残疾的关联：健康，衰老和身体成分研究。

背景技术抑郁症状和听力损失（HL）与事件致残风险的增加独立相关。尚不清楚增加的风险是否是累加的。方法采用Cox比例危险模型评估HL（正常，轻度，中度/重度）与晚期抑郁症状（在10个项目的流行病学研究中心-抑郁量表中得分≥8）的联合关联，在健康，老龄化和身体成分研究的2,196名参与者中，有行动不便的发作（很多困难或无法走路1/4英里和/或爬10个台阶）和日常生活活动中的任何残疾（ADL）。运作良好的70-79岁的老年人。针对年龄，种族，性别，教育程度，糖尿病，高血压和体重指数对模型进行了调整。结果相对于听力正常，无抑郁症状的参与者，轻度或中度/重度HL的无抑郁症状的参与者发生活动性和ADL残疾的风险增加（活动性障碍的危险比[HR]，轻度HL：1.34，95％置信区间[CI]：行动不便的置信区间[1.0]，1.64和HR，中度/重度HL：ADL残疾的1.37、95％CI：1.08、1.75和HR，轻度HL：1.32、95％CI：1.08、1.63和HR对于ADL残疾，中度/重度HL：1.42，95％CI：1.11，1.82）。在具有抑郁症状的参与者中，轻度HL（HR：1.71，95％CI：1.09，2.70）与意外行动不便的风险增加相关。结论独立于抑郁症状，不论严重程度如何，老年HL患者发生残疾的风险均较高。