Since the early 1990s, we have known that the adult brain is not static and has the capacity to repair itself. The delivery of various therapeutic factors and cells have resulted in some exciting pre-clinical and clinical outcomes in stroke models by targeting post-injury plasticity to enhance recovery. Developing a deeper understanding of the pathways that modulate plasticity will enable us to optimize delivery strategies for therapeutics and achieve more robust effects. Biomaterials are a key tool for the optimization of these potential treatments, owing to their biocompatibility and tunability. In this review, we identify factors and targets that impact plastic processes known to contribute to recovery, discuss the role of biomaterials in enhancing the efficacy of treatment strategies, and suggest combinatorial approaches based on the stage of injury progression.

从1990年代初期开始，我们就知道成年人的大脑不是静止的，而是具有自我修复的能力。通过靶向损伤后的可塑性来增强恢复能力，各种治疗因子和细胞的传递已在中风模型中产生了令人兴奋的临床前和临床结果。对调节可塑性的途径有了更深入的了解，将使我们能够优化治疗剂的递送策略并获得更强劲的效果。由于其生物相容性和可调性，生物材料是优化这些潜在疗法的关键工具。在这篇综述中，我们确定了影响已知有助于恢复的塑性过程的因素和目标，讨论了生物材料在增强治疗策略效力中的作用，