Hyperbeanols F-Q, which are twelve undescribed monoterpenoid polyprenylated acylphloroglucinols, and four known analogues were isolated from the dried flowers of Hypericum beanii. Their structures were elucidated by detailed HRESIMS and 1D and 2D NMR data analyses. The absolute configurations of hyperbeanols FH were established by the circular dichroism (CD) exciton chirality method. The plausible biosynthetic pathway speculation of hyperbeanols F-Q indicated that diverse reactions, including prenylation, 1,6-ene reaction, rearrangement, epoxidation and dehydration, contributed to their diverse skeletons. Hyperbeanols FI, O and hypercalin B exhibited moderate nitric oxide (NO) inhibitory activities in LPS-induced RAW 264.7 macrophages, with IC50 values in the range of 17.11-28.74 μM.

中文翻译：

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Hyperbeanols FQ，来自金丝桃花的多种单萜类聚异戊二烯化酰基间苯三酚

Hyperbeanols FQ，它是十二个未描述的单萜类聚异戊二烯化酰基间苯三酚和四个已知的类似物是从金丝桃干花中分离出来的。它们的结构通过详细的 HRESIMS 和 1D 和 2D NMR 数据分析得到阐明。hyperbeanols FH 的绝对构型是通过圆二色性 (CD) 激子手性方法建立的。hyperbeanols FQ 合理的生物合成途径推测表明，不同的反应，包括异戊二烯化、1,6-烯反应、重排、环氧化和脱水，促成了它们的不同骨架。Hyperbeanols FI、O 和 hypercalin B 在 LPS 诱导的 RAW 264.7 巨噬细胞中表现出中等的一氧化氮 (NO) 抑制活性，IC50 值在 17.11-28.74 μM 的范围内。