Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.,Nature Reviews Urology

当前位置： X-MOL 学术 › Nat. Rev. Urol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.
Nature Reviews Urology ( IF 15.3 ) Pub Date : 2019-03-01 , DOI: 10.1038/s41585-018-0135-5
J Quentin Clemens ₁ , Chris Mullins ₂ , A Lenore Ackerman ₃ , Tamara Bavendam ₂ , Adrie van Bokhoven ₄ , Benjamin M Ellingson ₅ , Steven E Harte ₆ , Jason J Kutch _{5,

7} , H Henry Lai ₈ , Katherine T Martucci ₉ , Robert Moldwin ₁₀ , Bruce D Naliboff ₁₁ , Michel A Pontari ₁₂ , Siobhan Sutcliffe ₁₃ , J Richard Landis ₁₄ ,

Affiliation

Department of Urology, University of Michigan, Ann Arbor, MI, USA.
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Beverly Hills, CA, USA.
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Division of Digestive Diseases, University of California, Los Angeles, CA, USA.
Departments of Anesthesiology and Medicine, University of Michigan, Ann Arbor, MI, USA.
Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.
Division of Urologic Surgery, Department of Surgery, and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pain Medicine, Stanford University, Palo Alto, CA, USA.
The Arthur Smith Institute for Urology, Zucker School of Medicine at Hofstra-Northwell, Lake Success, NY, USA.
Departments of Medicine, Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Department of Urology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Division of Public Health Sciences, Department of Surgery, and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.

中文翻译：

泌尿科慢性盆腔疼痛综合征：MAPP研究网络的见解。

泌尿科慢性盆腔疼痛综合征（UCPPS）包括间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性盆腔疼痛综合征，其特征是盆腔区域或生殖器的慢性疼痛常伴有尿频和尿急。尽管进行了大量研究，但尚未确定确切的病因危险因素或有效的治疗方法。慢性盆腔痛研究（MAPP）研究网络的多学科方法使用一种新颖的综合策略将UCPPS表征为可能涉及多种病因的系统性疾病。第一阶段，MAPP I，包括超过1,000名参与者，他们完成了深入的基线评估，然后进行了12个月的观察随访期。MAPP I研究表明，UCPPS疼痛和泌尿系统症状各不相同，仅具有中等相关性，应单独评估，症状发作是常见的，并且强度，持续时间和对生活质量的影响可能存在很大差异。UCPPS的纵向临床变化与大脑的结构和功能变化相关，许多患者经历了整体多感觉超敏反应。此外，UCPPS症状特征可通过生物学相关因素（例如免疫因子）加以区分。这些发现表明UCPPS患者具有客观的表型异常和独特的生物学特征，为UCPPS的研究和临床管理提供了新的基础。UCPPS的纵向临床变化与大脑的结构和功能变化相关，许多患者经历了整体多感觉超敏反应。此外，UCPPS症状特征可通过生物学相关因素（例如免疫因子）加以区分。这些发现表明UCPPS患者具有客观的表型异常和独特的生物学特征，为UCPPS的研究和临床管理提供了新的基础。UCPPS的纵向临床变化与大脑的结构和功能变化相关，许多患者经历了整体多感觉超敏反应。此外，UCPPS症状特征可通过生物学相关因素（例如免疫因子）加以区分。这些发现表明UCPPS患者具有客观的表型异常和独特的生物学特征，为UCPPS的研究和临床管理提供了新的基础。

更新日期：2019-01-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>