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A meta-analytical evaluation of the dual-hormone hypothesis: Does cortisol moderate the relationship between testosterone and status, dominance, risk taking, aggression, and psychopathy?
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2018-12-07 , DOI: 10.1016/j.neubiorev.2018.12.004
Tycho J. Dekkers , Joost A. Agelink van Rentergem , Bren Meijer , Arne Popma , Eline Wagemaker , Hilde M. Huizenga

According to the dual-hormone hypothesis, the relationship between testosterone and status-relevant behavior is moderated by cortisol, suggesting this relationship only exists when cortisol is low. In the current study, a meta-analysis (including 30 papers with 33 studies, 49 effect sizes, n = 8538) on the interaction effect of testosterone and cortisol on status-relevant behavior (i.e. status, dominance, risk taking, aggression, and psychopathy) was performed. There was only marginal support for the dual-hormone hypothesis: The effect size of the interaction between testosterone and cortisol on status-relevant behavior was significant but very small (r = -.061, p = .026), which was corroborated by follow-up meta-analyses on simple slopes on low and high cortisol. Effect sizes were largest for direct status measures, although not significantly different from other outcome measures. Similarly, effect sizes seemed larger for men than for women. However, robustness analyses indicated signs of publication bias, enhanced significance due to potential flexibility in data-analysis, and a lack of power of individual studies, emphasizing the need for a large, pre-registered study.



中文翻译:

对双激素假说的荟萃分析评估:皮质醇是否能调节睾丸激素与状态,优势,冒险精神,攻击性和精神病之间的关系?

根据双激素假说,皮质醇调节了睾丸激素与状态相关行为之间的关系,表明这种关系仅在皮质醇水平较低时存在。在当前的研究中, 对睾丸激素和皮质醇对与状态相关的行为(即状态,优势,冒险,攻击性和侵略性)的相互作用进行了荟萃分析(包括30篇论文,共33项研究,49个效应量,n = 8538)。进行了心理治疗)。对双激素假说只有勉强支持:睾丸激素和皮质醇之间的相互作用对与状态相关的行为的影响大小是显着的,但很小(r = -.061,p = .026),这通过对低和高皮质醇的简单斜率进行的后续荟萃分析得到了证实。对于直接状态测量,效果大小最大,尽管与其他结果测量没有显着差异。同样,男性的效果似乎比女性更大。但是,稳健性分析表明存在出版偏见的迹象,由于数据分析中的潜在灵活性而增加了重要性,并且缺乏个别研究的能力,从而强调了需要进行大量预先注册的研究。

更新日期:2018-12-07
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