Poly (ADP-ribose) polymerase-1 (PARP1) is a major member of the PARP superfamily that is involved in DNA damage signalling and other important cellular processes. Here we report the development of a small molecule targeting PARP1 based on the PROTAC strategy. In the MDA-MB-231 cell line, the representative compound 3 can induce significant PARP1 cleavage and programmed cell death.

中文翻译：

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靶向PARP1的PROTAC小分子诱导MDA-MB-231乳腺癌细胞凋亡†

聚（ADP-核糖）聚合酶-1（PARP1）是PARP超家族的主要成员，该家族参与DNA损伤信号传导和其他重要的细胞过程。在这里，我们报告了基于PROTAC策略的靶向PARP1的小分子的发展。在MDA-MB-231细胞系中，代表性化合物3可以诱导明显的PARP1裂解和程序性细胞死亡。