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Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria.
ACS Omega ( IF 4.1 ) Pub Date : 2018-12-05 , DOI: 10.1021/acsomega.8b02438
Zil-E Huma 1 , Akash Gupta 2 , Ibrahim Javed 1, 3 , Riddha Das 2 , Syed Zajif Hussain 1 , Shazia Mumtaz 1 , Irshad Hussain 1 , Vincent M Rotello 2
Affiliation  

Bacterial multidrug resistance (MDR) is a serious healthcare issue caused by the long-term subtherapeutic clinical treatment of infectious diseases. Nanoscale engineering of metal nanoparticles has great potential to address this issue by tuning the nano-bio interface to target bacteria. Herein, we report the use of branched polyethylenimine-functionalized silver nanoclusters (bPEI-Ag NCs) to selectively kill MDR pathogenic bacteria by combining the antimicrobial activity of silver with the selective toxicity of bPEI toward bacteria. The minimum inhibitory concentration of bPEI-Ag NCs was determined against 12 uropathogenic MDR strains and found to be 10- to 15-fold lower than that of PEI and 2- to 3-fold lower than that of AgNO3 alone. Cell viability and hemolysis assays demonstrated the biocompatibility of bPEI-Ag NCs with human fibroblasts and red blood cells, with selective toxicity against MDR bacteria.

中文翻译:

阳离子银纳米团簇作为抗多药细菌的强效抗菌剂。

细菌多药耐药性(MDR)是由传染病的长期亚治疗临床治疗引起的严重的医疗保健问题。金属纳米粒子的纳米工程通过调整纳米生物界面以靶向细菌,具有解决这个问题的巨大潜力。在此,我们报告了使用支化聚乙烯亚胺功能化银纳米簇 (bPEI-Ag NCs) 通过将银的抗菌活性与 bPEI 对细菌的选择性毒性相结合来选择性杀死 MDR 致病菌。bPEI-Ag NCs 的最低抑制浓度是针对 12 种尿路致病性 MDR 菌株测定的,发现比 PEI 低 10 到 15 倍,比单独的 AgNO3 低 2 到 3 倍。
更新日期:2018-12-05
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