当前位置：
X-MOL 学术
›
Ophthalmology
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Retinal Nerve Fiber Layer Thickness in a Multiethnic Normal Asian Population: The Singapore Epidemiology of Eye Diseases Study.
Ophthalmology ( IF 13.7 ) Pub Date : 2018-12-04 , DOI: 10.1016/j.ophtha.2018.11.031 Henrietta Ho 1 , Yih-Chung Tham 2 , Miao Li Chee 2 , Yuan Shi 2 , Nicholas Y Q Tan 2 , Kah-Hie Wong 3 , Shivani Majithia 4 , Carol Y Cheung 5 , Tin Aung 6 , Tien Yin Wong 6 , Ching-Yu Cheng 6
Ophthalmology ( IF 13.7 ) Pub Date : 2018-12-04 , DOI: 10.1016/j.ophtha.2018.11.031 Henrietta Ho 1 , Yih-Chung Tham 2 , Miao Li Chee 2 , Yuan Shi 2 , Nicholas Y Q Tan 2 , Kah-Hie Wong 3 , Shivani Majithia 4 , Carol Y Cheung 5 , Tin Aung 6 , Tien Yin Wong 6 , Ching-Yu Cheng 6
Affiliation
PURPOSE
To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain (SD) OCT in a multiethnic Asian population.
DESIGN
Population-based, cross-sectional study.
PARTICIPANTS
Ethnic Chinese, Malay, and Indian adults older than 48 years without glaucoma who were recruited from the Singapore Epidemiology of Eye Diseases Study.
METHODS
All participants underwent standardized systemic and ocular examinations. Retinal nerve fiber layer thickness was measured using SD OCT. Participants with poor-quality scans were excluded. Linear regression models were used to investigate the associations of ocular and systemic factors with average RNFL thickness. Generalized estimating equation models were used to account for correlation between both eyes.
MAIN OUTCOME MEASURE
Average RNFL thickness.
RESULTS
Four thousand four hundred seventy-five participants (8178 eyes) consisting of 1371 Chinese, 1303 Malay, and 1801 Indian adults contributed to this analysis. Average RNFL thickness measured was 95.7±9.6 μm in Chinese participants, 94.9±10.6 μm in Malay participants, and 87.3±10.6 μm in Indian participants (P < 0.001). Multivariate analysis adjusted for age, gender, and ethnicity revealed a reduction in RNFL thickness with increased intraocular pressure and axial length (P < 0.001 for both), as well as a diagnosis of diabetes (P = 0.04); greater RNFL thickness was associated with increased disc area (P < 0.001), signal strength (P < 0.001), and low-density lipoprotein cholesterol (P = 0.02). When these significant variables were taken into account, the average RNFL thickness of Indian participants was significantly thinner compared with Chinese participants (7.45 μm thinner on average [95% confidence interval, 6.75-8.15 μm; P < 0.001]), whereas there was no significant difference in average RNFL thickness between Malay and Chinese participants (P = 0.15).
CONCLUSIONS
Average and regional RNFL thicknesses were significantly thinner in Indian eyes compared with Chinese and Malay eyes. Results of the study highlight the need to acquire more refined normative data for the comparison of individual patients with others of similar ethnic background while accounting for ocular factors that could influence RNFL thickness. This in turn may improve the sensitivity and specificity of glaucoma detection.
更新日期：2018-12-04
京公网安备 11010802027423号