Many first-line treatments for neglected tropical diseases identified by the World Health Organization (WHO) are limited by one or more of the following: the development of drug resistance, toxicity, and side effects, lack of selectivity, narrow therapeutic indices, route of administration, and bioavailability. As such, there is an urgent need to develop viable alternatives to overcome these limitations. The following review provides an overview of all existing metal complexes studied and evaluates the status of these complexes on the respective disease of choice.

中文翻译：

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抗被忽视的热带疾病的金属化合物

世界卫生组织（WHO）确定的许多被忽视的热带病的一线治疗受到以下一个或多个因素的限制：耐药性，毒性和副作用的发展，缺乏选择性，狭窄的治疗指数，治疗途径给药和生物利用度。因此，迫切需要开发可行的替代方案来克服这些限制。以下综述概述了所有已研究的金属配合物，并评估了这些配合物在各自选择的疾病上的状况。