Objective

APOE status has been associated to affective symptoms in cognitively impaired subjects, with conflicting results.

Methods

Databases CINAHL, Embase, PsychINFO and PubMed were searched for studies evaluating APOE genotype with affective symptoms in MCI and AD dementia. Symptoms were meta-analyzed separately and possible sources of heterogeneity were examined.

Results

Fifty-three abstracts fulfilled the eligibility criteria. No association was found between the individual symptoms and APOE ε4 carriership or zygosity. For depression and anxiety, only pooled unadjusted estimates showed positive associations with between-study heterogeneity, which could be explained by variation in study design, setting and way of symptom assessment.

Conclusions

There is no evidence that APOE ε4 carriership or zygosity is associated with the presence of depression, anxiety, apathy, agitation, irritability or sleep disturbances in cognitively impaired subjects. Future research should shift its focus from this single polymorphism to a more integrated view of other biological factors.

中文翻译：

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轻度认知障碍和阿尔茨海默氏病痴呆症中载脂蛋白E和情感症状的系统评价和荟萃分析

客观的

APOE状态已与认知障碍受试者的情感症状相关，结果相互矛盾。

方法

搜索数据库CINAHL，Embase，PsychINFO和PubMed，以评估在MCI和AD痴呆症中具有情感症状的APOE基因型的研究。分别对症状进行荟萃分析，并检查可能的异质性来源。

结果

共有53个摘要符合资格标准。在个体症状与APOEε4携带力或接合性之间未发现关联。对于抑郁症和焦虑症，只有汇总的未经调整的估计值显示出研究之间异质性的正相关性，这可以通过研究设计，设置和症状评估方式的差异来解释。

结论

没有证据表明APOEε4携带力或合子性与认知障碍受试者的抑郁，焦虑，冷漠，激动，易怒或睡眠障碍有关。未来的研究应将其重点从单一多态性转移到其他生物学因素的更综合的观点。