Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed ubiquitously on the cell surface and in the extracellular matrix where they interact with a wide range of ligands to regulate many aspects of cellular function. The capacity of the side glycosaminoglycan chain heparan sulfate (HS) being able to interact with diverse protein ligands relies on its complex structure that is generated by a controlled biosynthesis process, involving the actions of glycosyl-transferases, sulfotransferases and the glucuronyl C5-epimerase. It is believed that activities of the modification enzymes control the HS structures that are designed to serve the biological functions in a given cell or biological status. In this review, we briefly discuss recent understandings on the roles of HSPG in cytokine stimulated cellular signaling, focusing on FGF, TGF-β, Wnt, Hh, HGF and VEGF.

硫酸乙酰肝素蛋白聚糖（HSPG）是在细胞表面和细胞外基质中普遍表达的大分子糖缀合物，它们在其中与多种配体相互作用以调节细胞功能的许多方面。侧糖胺聚糖链硫酸乙酰肝素（HS）能够与多种蛋白质配体相互作用的能力取决于其复杂的结构，该结构是由受控的生物合成过程产生的，涉及糖基转移酶，磺基转移酶和葡糖醛酸酰基C5-表异构酶的作用。相信修饰酶的活性控制被设计用于在给定细胞或生物学状态下发挥生物学功能的HS结构。在这篇综述中，我们简要讨论了关于HSPG在细胞因子刺激的细胞信号转导中的作用的最新理解，