A sensitive and reliable electrochemical determination of natural alkaloid palmatine was proposed based on CeO₂/RGO/MWCNT ternary composite modified screen printed carbon electrode. The proposed ternary composite was prepared via simple hydrothermal synthesis method without using of hazardous chemicals. The surface morphology, elemental compositions, functional group moieties, crystalline structure and defects and disorder of the prepared CeO₂/RGO/MWCNT ternary composite was confirmed by various spectrometric techniques. In addition, the electrochemical properties of the modified electrodes were investigated by voltammetry techniques. Notably, the proposed CeO₂/RGO/MWCNT modified electrode exhibited two linear concentration ranges from 0.1 to 118 µM and 118 to 1198 µM with the lowest detection limit of 0.03 µM for the determination of palmatine at neutral condition. Additionally, the proposed electrode material showed a good sensitivity of 1. 791 µA µM⁻¹ cm⁻² and detects the palmatine with good selectivity in the presence of interfering substances. Furthermore, the practical feasibility of the sensor was analyzed in human serum and urine samples.

提出了基于CeO ₂ / RGO / MWCNT三元复合修饰丝网印刷碳电极的灵敏可靠的电化学方法测定天然生物碱棕榈碱。所提出的三元复合物是通过简单的水热合成方法制备的，没有使用有害化学物质。通过各种光谱技术证实了所制备的CeO ₂ / RGO / MWCNT三元复合材料的表面形貌，元素组成，官能团部分，晶体结构以及缺陷和无序。另外，通过伏安法研究了改性电极的电化学性能。值得注意的是，拟议的CeO ₂/ RGO / MWCNT修饰电极在中性条件下测定棕榈碱的线性浓度范围为0.1至118 µM和118至1198 µM，最低检出限为0.03 µM。另外，所提出的电极材料显示出良好的灵敏度。1. 791 µA µM ^-1 cm ^-2，并且在存在干扰物质的情况下以良好的选择性检测棕榈碱。此外，在人血清和尿液样品中分析了传感器的实际可行性。