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State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research.
Acta Pharmacologica Sinica ( IF 8.2 ) Pub Date : 2018-11-28 , DOI: 10.1038/s41401-018-0190-8
Lu Lu 1 , Zhou-Yue Wu 1 , Xin Li 2 , Feng Han 1, 2
Affiliation  

Cardiovascular diseases, neuropsychiatric disorders, and cancers seriously endanger human health. Mechanistic and pharmacological mechanisms of candidate drugs are central to the translational paradigm. Since many signal transduction and molecular events are implicated in these diseases, a novel method to interrogate the key pharmacological mechanisms is required to accelerate innovative drug discovery. Much attention now focuses on the real-time visualization of molecular disease events to yield new insights to the pathogenesis of the diseases. This review focuses on recent advances in the development of chemical probes for imaging pathological events to facilitate the study of the underlying pharmacodynamics and toxicity involved. As reviewed here, optical imaging is now frequently viewed as an indispensable technique in the field of biological research. Promoting interdisciplinary collaboration among chemistry, biology and medicine, is necessary to further refine functional fluorescent probes for diagnostic and therapeutic applications.

中文翻译:

最新技术:用于生物成像和药理研究的功能性荧光探针。

心血管疾病,神经精神疾病和癌症严重危害人类健康。候选药物的机制和药理机制是翻译范式的核心。由于这些疾病涉及许多信号转导和分子事件,因此需要一种新颖的方法来询问关键的药理机制,以加速创新药物的发现。现在,很多注意力都集中在分子疾病事件的实时可视化上,从而对疾病的发病机理产生新的见解。这篇综述着重于对病理事件进行成像的化学探针的开发方面的最新进展,以促进对所涉及的基本药效学和毒性的研究。正如这里所评论的 光学成像现在经常被视为生物学研究领域中必不可少的技术。促进化学,生物学和医学之间的跨学科合作,对于进一步完善用于诊断和治疗应用的功能性荧光探针是必不可少的。
更新日期:2019-05-16
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