OBJECTIVE Adolescents with excess weight are particularly sensitive to stress, which may contribute to the presence of emotional eating behaviors. It is proposed that this may be due to alterations in the connectivity between hypothalamic networks and regions of the "emotional nervous system," involved in the regulation of energy balance and stress processing. However, this remains to be clarified in adolescents with excess weight. METHOD We investigated whole-brain differences in the functional connectivity of the medial and lateral hypothalamus (MH and LH) between adolescents with excess weight (EW, n = 53; mean age = 14.64 years, SD = 1.78) and normal weight (NW, n = 51; mean age = 15.29 years, SD = 1.75) using seed-based resting-state analyses. Then, in a subset of 22 adolescents with EW (mean age = 15.75 years, SD = 1.70) and 32 with NW (mean age = 15.27, SD = 2.03), we explored for group interactions between the MH/LH networks and stress response in the Trier Social Stress Task (TSST) and emotional eating, assessed with the Dutch Eating Behavior Questionnaire (DEB-Q). RESULTS Compared to NW, EW showed higher functional connectivity in the LH-orbitofrontal cortex, ventral striatum, anterior insula, and in the MH-middle temporal cortex networks. EW also showed lower connectivity in the LH-cerebellum, and in the MH-middle prefrontal, pre-, and postcentral gyri networks. In EW, higher connectivity of the LH-nucleus accumbens and LH-midbrain networks were associated with stress response. Higher connectivity in the LH-midbrain was also associated with a greater presence of emotional eating behaviors in EW. CONCLUSION Adolescents with EW showed functional connectivity alterations within both MH/LH networks. Alterations in the LH network were linked with higher levels of stress response and emotional-driven eating patterns.

中文翻译：

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青少年体重过重的下丘脑网络：与压力有关的连通性和情绪饮食的关联。

目的体重过重的青少年对压力特别敏感，这可能有助于情绪饮食行为的出现。提出这可能是由于下丘脑网络和“情绪神经系统”区域之间的连通性改变，参与能量平衡和压力处理的调节。但是，对于体重过重的青少年，这仍有待澄清。方法我们调查了超重（EW，n = 53;平均年龄= 14.64岁，SD = 1.78）和正常体重（NW， n = 51；平均年龄= 15.29岁，SD = 1.75）使用基于种子的静止状态分析。然后，在22名EW青少年中（平均年龄= 15.75岁，SD = 1）。70）和32（西北）（平均年龄= 15.27，SD = 2.03），我们通过特里尔社交压力任务（TSST）和情绪饮食研究了MH / LH网络与压力反应之间的群体相互作用，并通过荷兰人饮食行为进行了评估问卷（DEB-Q）。结果与NW相比，EW在LH-眶额皮层，腹侧纹状体，前岛和MH-颞颞皮层网络中显示出更高的功能连通性。EW在LH小脑以及MH中央前额叶，中央前和中央后回神经网络中的连接性也较低。在电子战中，伏隔核和左脑中脑网络的更高连通性与应激反应有关。LH-中脑的较高连通性也与EW中更多的情绪饮食行为有关。结论EW青少年在MH / LH网络中均显示出功能连通性改变。LH网络的改变与较高水平的压力反应和情绪驱动的饮食方式有关。