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Transgenerational Epigenetic Inheritance
Annual Review of Genetics ( IF 11.1 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1146/annurev-genet-120417-031404
Ana Bošković 1 , Oliver J. Rando 1
Affiliation  

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in multicellular organisms. In addition to surveying examples of epivariation that may arise stochastically or in response to unknown stimuli, we also discuss the induction of heritable epigenetic changes by genetic or environmental perturbations. Mechanistically, we discuss the increasingly well-understood molecular pathways responsible for epigenetic inheritance, with a focus on the unusual features of the germline epigenome.

中文翻译:


跨代表观遗传

基因组DNA的遗传是绝大多数生物遗传的基础,但是数十年来,很明显,可以将更多的表观遗传信息传递给子孙后代。在这里,我们回顾了通过多细胞生物中的种系进行跨代表观遗传遗传的主要模型系统。除了调查可能随机或响应未知刺激而产生的表观变异的例子外,我们还讨论了通过遗传或环境扰动诱发可遗传表观遗传变化的方法。从机理上讲,我们讨论了负责表观遗传的越来越多的分子途径,重点是种系表观基因组的异常特征。

更新日期:2018-11-26
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