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Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1039/c8cc07735e
Wei Liu 1, 2, 3, 4 , Yao-Qian Hu 1, 2, 3, 4 , Xiao-Yi Hong 1, 2, 3, 4 , Guo-Xing Li 1, 2, 3, 4 , Xiao-Bo Huang 1, 2, 3, 4 , Wen-Xia Gao 1, 2, 3, 4 , Miao-Chang Liu 1, 2, 3, 4 , Yuanzhi Xia 1, 2, 3, 4 , Yun-Bing Zhou 1, 2, 3, 4 , Hua-Yue Wu 1, 2, 3, 4
Affiliation  

A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.

中文翻译:

通过2-炔基硫代苯甲醚与α-氧代羧酸的自由基环化反应 直接合成3-酰基苯并噻吩

已经描述了2-炔基硫代苯甲醚与具有AgNO 3的α-氧代羧酸的自由基级联环化。该反应提供了从简单的化学原料直接获得3-酰基苯并噻吩的新颖途径。特别地,该方法的实用性通过其在聚合抑制剂和雷洛昔芬前体的合成中的应用而得到证明。
更新日期:2018-11-26
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