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Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities
Phytochemistry ( IF 3.8 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.phytochem.2018.11.002 Ya-Nan Qiao , Yong Sun , Tao Shen , Jiao-Zhen Zhang , Jin-Chuan Zhou , Yi Li , Wang Chen , Zhao-Jie Ren , Yue-Lan Li , Xue Wang , Hong-Xiang Lou
Phytochemistry ( IF 3.8 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.phytochem.2018.11.002 Ya-Nan Qiao , Yong Sun , Tao Shen , Jiao-Zhen Zhang , Jin-Chuan Zhou , Yi Li , Wang Chen , Zhao-Jie Ren , Yue-Lan Li , Xue Wang , Hong-Xiang Lou
Six previously undescribed labdane diterpenoids, frullanians A-F, along with five known diterpenoids, were isolated from the Chinese liverwort Frullania hamatiloba Stephani. Their structures were determined using NMR data, electronic circular dichroism (ECD) calculations as well as the single crystal X-ray diffraction measurement. NAD(P)H: QR (quinone reductase) assay demonstrated that frullanian D and four known compounds displayed antioxidant effect mediated via Nrf2 (Nuclear factor-erythroid 2-related factor 2) induction. Further investigation of the most bioactive frullanian D in MOVAS cells revealed that it ameliorated H2O2-induced oxidative insults without toxicity by increasing cell viability, attenuating morphological changes, and reducing intracellular ROS production. In addition, frullanian D promoted the nuclear translocation of Nrf2 and upregulated the expressions of antioxidant proteins NQO1 (NAD(P)H quinone oxidoreductase 1) and γ-GCS (γ-glutamyl cysteine synthetase). Docking analysis using MOE software further supported the activation of the Nrf2 pathway by frullanian D.
更新日期：2019-02-01
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