Hypertension (HTN) is a major risk factor for coronary artery disease. Its frequency is increasing globally. The aim of our study was to evaluate the reference range of blood pressure (BP) in the Iranian population stratified for age and gender. A total of 1449 subjects without diabetes, CVD, dyslipidemia, HTN history and with a normal BMI (18.5 ≤ BMI<25) were recruited in the present study. Participants were enrolled from the Mashhad stroke and heart atherosclerotic disorder study. Anthropometric indices and demographic data were collected by two health care specialists. A quantile regression model was used to estimate the expected systolic BP (SBP) and diastolic BP (DBP) at specific ages. A P-value of <.05 was considered significant for all analyses. All statistical analyses were performed using R (version 3.4.1) and SPSS software. The population included more men than women (51.6% vs. 48.4%). The mean and standard deviation of age in men (47.5 ± 8.4) was 2 years higher than women (45.63 ± 7.9; P < .001). SBP and DBP were higher in men than women (P < .001). By using a quantile regression model, we concluded that the 5th to 90th percentile of SBP in men, aged 30–69 years, ranged from 95 to 148.08 mm Hg and in women ranged from 86.66 to 140 mm Hg. The 5th to 90th percentile of DBP in men, aged 30–69 years, ranged from 60 to 91.66 mm Hg and in women ranged from 60 to 91.22 mm Hg. We have, for the first time, established the BP percentiles (1st, 5th, 10th, 50th, 90th, 95th, 99th) in an Iranian population stratified by age and gender. These data suggest that a local program for health promotion is necessary for the early identification of HTN in adults aged ≥30 years.

高血压（HTN）是冠状动脉疾病的主要危险因素。它的频率在全球范围内不断增加。我们研究的目的是评估按年龄和性别分层的伊朗人口的参考血压范围。本研究共招募了1449名无糖尿病，CVD，血脂异常，HTN病史且BMI正常（18.5≤BMI <25）的受试者。参与者来自Mashhad中风和心脏动脉粥样硬化疾病研究。人体健康指数和人口统计学数据是由两名医疗保健专家收集的。分位数回归模型用于估计特定年龄的预期收缩压（SBP）和舒张压（DBP）。一个P<.05的-值对于所有分析都被认为是重要的。所有统计分析均使用R（3.4.1版）和SPSS软件进行。人口中男性多于女性（51.6％对48.4％）。男性（47.5±8.4）的平均年龄和标准差比女性（45.63±7.9；P  <.001）高2岁。男性的SBP和DBP高于女性（P <.001）。通过使用分位数回归模型，我们得出结论，年龄在30-69岁之间的男性SBP的第5个百分点至第90个百分点，介于95至148.08毫米汞柱之间，而女性则介于86.66至140毫米汞柱之间。年龄在30-69岁之间的男性，其DBP的第5个百分点至第90个百分点，范围是60至91.66毫米汞柱，而女性则是60至91.22毫米汞柱。我们首次在按年龄和性别分层的伊朗人口中建立了BP百分位（第1、5、10、50、90、95、99位）。这些数据表明，要在30岁以上的成年人中早期识别HTN，就必须制定一项当地的健康促进计划。