The demand for renewable and sustainable fuel has prompted the rapid development of advanced nanotechnologies to effectively harness solar power. The construction of photosynthetic biohybrid systems (PBSs) aims to link preassembled biosynthetic pathways with inorganic light absorbers. This strategy inherits both the high light-harvesting efficiency of solid-state semiconductors and the superior catalytic performance of whole-cell microorganisms. Here, we introduce an intracellular, biocompatible light absorber, in the form of gold nanoclusters (AuNCs), to circumvent the sluggish kinetics of electron transfer for existing PBSs. Translocation of these AuNCs into non-photosynthetic bacteria enables photosynthesis of acetic acid from CO₂. The AuNCs also serve as inhibitors of reactive oxygen species (ROS) to maintain high bacterium viability. With the dual advantages of light absorption and biocompatibility, this new generation of PBS can efficiently harvest sunlight and transfer photogenerated electrons to cellular metabolism, realizing CO₂ fixation continuously over several days.

对可再生和可持续燃料的需求促使先进的纳米技术迅速发展，以有效地利用太阳能。光合作用生物杂交系统（PBS）的建设旨在将预组装的生物合成途径与无机光吸收剂联系起来。该策略既继承了固态半导体的高集光效率，又继承了全细胞微生物的出色催化性能。在这里，我们以金纳米团簇（AuNCs）的形式引入一种细胞内生物相容的光吸收剂，以规避现有PBS的电子转移反应迟钝。这些AuNCs易位到非光合细菌中，可以从CO ₂光合作用合成乙酸。AuNCs还用作活性氧（ROS）的抑制剂，以保持较高的细菌生存能力。凭借光吸收和生物相容性的双重优势，这种新一代的PBS可以有效地收集阳光并将光生电子转移到细胞代谢中，并在几天内连续实现CO ₂固定。