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Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review
International Materials Reviews ( IF 16.1 ) Pub Date : 2018-04-18 , DOI: https://doi.org/10.1080/09506608.2018.1460943
Naseer Iqbal, Abdul Samad Khan, Anila Asif, Muhammad Yar, John W. Haycock, Ihtesham Ur Rehman

Tissue engineering and regenerative medicine are emerging as future approaches for the treatment of acute and chronic diseases. Numerous clinical conditions exist today and include congenital disorders, trauma, infection, inflammation, and cancer, in which hard and soft tissue damage, organ failure and loss are still not treated effectively. Researchers are constantly developing new biomaterials and tissue-engineered technologies to stimulate tissue regeneration. Various emerging approaches according to organ, tissue, disease and disorder are identified. Irrespective, engineered biomaterials are required to regenerate and ultimately reproduce the original physiological, biological, chemical, and mechanical properties. Biodegradable materials have been used extensively as regenerative therapies. The selection, design, biological and physicochemical properties of these materials are important and must be considered for stimulating tissue growth. In this review, we critique recently developed biodegradable materials for tissue regeneration of some targeted organs e.g., skin, nerves, blood vessels, heart, cornea, trachea, dental/oral structure and bones.

中文翻译:

用于组织工程范式的可生物降解聚合物的最新概念:严格的审查。

组织工程学和再生医学正在成为治疗急性和慢性疾病的未来方法。今天存在许多临床疾病,包括先天性疾病,创伤,感染,炎症和癌症,其中硬组织和软组织损伤,器官衰竭和丢失仍未得到有效治疗。研究人员正在不断开发新的生物材料和组织工程技术来刺激组织再生。根据器官,组织,疾病和病症,鉴定了各种新兴方法。无论如何,都需要经过工程改造的生物材料来再生并最终复制出原始的生理,生物学,化学和机械特性。可生物降解的材料已被广泛用作再生疗法。选择,设计,这些材料的生物学和物理化学特性很重要,并且在刺激组织生长时必须考虑这些特性。在这篇评论中,我们批评了最近开发的可生物降解的材料,用于某些目标器官的组织再生,例如皮肤,神经,血管,心脏,角膜,气管,牙齿/口腔结构和骨骼。
更新日期:2018-09-30
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