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Quis Custodiet Ipsos Custodes? Regulation of Cell-Mediated Immune Responses Following Viral Lung Infections
Annual Review of Virology ( IF 11.3 ) Pub Date : 2018-09-28 00:00:00 , DOI: 10.1146/annurev-virology-092917-043515
Meredith C. Rogers 1, 2 , John V. Williams 1, 3
Affiliation  

Viral lung infections are leading causes of morbidity and mortality. Effective immune responses to these infections require precise immune regulation to preserve lung function after viral clearance. One component of airway pathophysiology and lung injury associated with acute respiratory virus infection is effector T cells, yet these are the primary cells required for viral clearance. Accordingly, multiple immune mechanisms exist to regulate effector T cells, limiting immunopathology while permitting clearance of infection. Much has been learned in recent years about regulation of T cell function during chronic infection and cancer, and it is now clear that many of these mechanisms also control inflammation in acute lung infection. In this review, we focus on regulatory T cells, inhibitory receptors, and other cells and molecules that regulate cell-mediated immunity in the context of acute respiratory virus infection.

中文翻译:


Quis Custodiet Ipsos Custodes?病毒肺感染后细胞介导的免疫反应的调节。

病毒性肺部感染是发病率和死亡率的主要原因。对这些感染的有效免疫反应需要精确的免疫调节,以在病毒清除后保持肺功能。效应器T细胞是与急性呼吸道病毒感染相关的气道病理生理学和肺损伤的一个组成部分,但这些是清除病毒所需的主要细胞。因此,存在多种免疫机制来调节效应T细胞,限制免疫病理学,同时允许清除感染。近年来,关于在慢性感染和癌症期间调节T细胞功能的知识很多,现在很明显,这些机制中的许多也可以控制急性肺部感染中的炎症。在这篇评论中,我们重点介绍调节性T细胞,抑制性受体,

更新日期:2018-09-28
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