A slight increase (1%) in endothelial function is associated with reduction of cardiovascular risks by 13% in individuals with cardiovascular disease risk, including those with hypertension. Thus, we conducted a systematic review and meta-analysis to assess the efficacy of exercise training on endothelial function in individuals with hypertension.We included randomized clinical trials (RCTs) with adult participants diagnosed with hypertension undergoing exercise training (≥4 weeks), and the primary outcome was endothelial function, measured by flow-mediated dilatation (FMD). Five studies comprising a total of 362 participants (252 exercise and 110 controls; 59.3 years old, ranged from 52.0 to 67.2 years) were included in the meta-analysis. The pooled mean estimate indicated increased FMD after exercise training of 1.45 (P = .001), and 95% confidence interval −0.11 to 3.00 compared with control comparators. The studies were characterized by significant heterogeneity (χ² = 23.34, P < .001, I² = 70%). The present results are consistent with the notion that aerobic exercise training elicits favorable adaptations in endothelial function in individuals with hypertension. However, more studies are needed to make more definitive conclusions.

患有心血管疾病风险的个体（包括高血压患者）的内皮功能轻微升高（1％）可将心血管疾病风险降低13％。因此，我们进行了系统的回顾和荟萃分析，以评估运动训练对高血压患者内皮功能的功效。主要结局是通过血流介导的扩张（FMD）测量的内皮功能。荟萃分析包括五项研究，共362名参与者（252名运动者和110名对照； 59.3岁，年龄从52.0岁至67.2岁）。合并的平均估计值表明运动训练后FMD增加了1.45（P = 0.001），与控制比较器相比，95％置信区间为−0.11至3.00。通过显著异质性研究进行了表征（χ ²  = 23.34，P  <0.001，我²  = 70％）。目前的结果与有氧运动训练在高血压患者的内皮功能中产生良好的适应性这一观点是一致的。但是，需要进行更多的研究才能得出更明确的结论。