While still considered an experimental procedure in most countries, ovarian tissue cryopreservation and transplantation has been increasingly applied worldwide to restore fertility in patients with malignant and non-malignant pathologies with risk of premature ovarian insufficiency. It has yielded more than 130 live births up to now and almost all transplanted patients recovered their ovarian function. This study summarizes ovarian tissue cryopreservation and transplantation indications, procedures, their efficacy and main results and proposes different strategies to improve this strategy. Although the main focus of this study is on ovarian tissue cryopreservation and transplantation as a strategy to restore fertility, we believe that it is also important to discuss other applications for this approach.

卵巢组织冷冻保存和移植在大多数国家/地区仍被视为实验方法，但在全世界范围内已越来越多地应用于卵巢组织冷冻保存和移植，以恢复具有卵巢早衰风险的恶性和非恶性病变患者的生育能力。迄今为止，它已经产生了130多个活产，几乎所有移植患者都恢复了卵巢功能。这项研究总结了卵巢组织冷冻保存和移植的适应症，程序，其功效和主要结果，并提出了不同的策略来改善这一策略。尽管本研究的主要重点是卵巢组织冷冻保存和移植，以作为恢复生育力的策略，但我们认为，讨论该方法的其他应用也很重要。