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Breath acetone as a marker of energy balance: an exploratory study in healthy humans
Nutrition & Diabetes ( IF 6.1 ) Pub Date : 2018-09-10 , DOI: 10.1038/s41387-018-0058-5
Fabian Bovey , Jérémy Cros , Béla Tuzson , Kevin Seyssel , Philippe Schneiter , Lukas Emmenegger , Luc Tappy

An exploratory study was performed on eight healthy volunteers to assess how short-term changes in energy balance and dietary carbohydrate content impact breath acetone concentrations. Participants were studied on three occasions: on each occasion, they remained fasted and in resting conditions during the first 2 h to assess basal breath acetone and blood beta-hydroxybutyrate (BOHB). During the next 6 h, they remained fasted on one occasion (F), or were fed hourly high carbohydrate (HC) or low-carbohydrate (LC) meals to induce a positive energy balance on the other two occasions. They remained in resting conditions during 4 h, then performed a 2-hour low intensity exercise (25 W) inducing a negative energy balance. In resting conditions, breath acetone and blood BOHB concentrations increased progressively compared to basal values in F, but decreased and remained low throughout the test in HC. With LC, breath acetone increased progressively, while blood BOHB decreased. This exploratory study indicates that breath acetone reliably detects a stimulation of ketogenesis during a short-term fast. It also suggests that LC and HC differentially impact BOHB and acetone production and utilization, and reveals possible limitations to the use of breath acetone as a marker of energy balance.



中文翻译:

呼吸丙酮作为能量平衡的标志:一项针对健康人类的探索性研究

对八名健康志愿者进行了一项探索性研究,以评估能量平衡和饮食中碳水化合物含量的短期变化如何影响呼吸中丙酮的浓度。对参与者进行了三种情况的研究:在每种情况下,他们在前2小时内都保持禁食和休息状态,以评估基础呼吸丙酮和血液中的β-羟基丁酸酯(BOHB)。在接下来的6小时内,他们一次保持禁食(F),或者每小时进食高碳水化合物(HC)或低碳水化合物(LC)的进餐,以在其他两种情况下产生积极的能量平衡。他们在4小时内保持静止状态,然后进行2小时的低强度运动(25 W),引起负能量平衡。在静息状态下,与F中的基础值相比,呼吸中丙酮和血液中BOHB的浓度逐渐增加,但在整个HC测试中有所下降,并保持较低水平。使用LC时,呼吸丙酮逐渐增加,而血液中的BOHB下降。这项探索性研究表明,呼吸丙酮可以在短期禁食期间可靠地检测出对生酮的刺激。它还表明,LC和HC差异影响BOHB和丙酮的生产和利用,并揭示了使用呼气丙酮作为能量平衡的标志可能存在的局限性。

更新日期:2019-11-18
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