Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation. Thus, scarring can also be induced in the dermis, in the absence of an actual wound, during chronic inflammatory processes. Considering the significant portion of the population that is subject to abnormal scarring, this review critically discusses the state-of-the-art and upcoming therapies in skin scarring and fibrosis.

中文翻译：

---

当前和即将到来的调节皮肤瘢痕形成和纤维化的疗法。

皮肤是人体最大的器官。由于是人体与外部环境之间的界面，因此很容易受到身体伤害。为了维持生命，大自然赋予了皮肤快速的愈合反应，总是在受伤的皮肤区域形成疤痕。在许多情况下，皮肤重塑可能受损，从而导致局部肥大性瘢痕或瘢痕loid。还应该考虑到，瘢痕形成过程是伤口愈合反应的一部分，而伤口愈合反应总是始于炎症。因此，在慢性炎症过程中，在没有实际伤口的情况下，还可在真皮中诱发瘢痕形成。考虑到人口中有很大一部分人会遭受异常的疤痕形成，因此本综述严格讨论了皮肤疤痕和纤维化的最新技术和即将到来的疗法。