The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.

中文翻译：

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基质建模和重塑：调节组织稳态和疾病的生物相互作用。

细胞外基质的整体结构和架构会随着时间的流逝在组成，形式和功能上发生巨大变化。随机性在发育过程中开始，对于维持机体动态平衡至关重要，并且与包括纤维化和癌症在内的许多病理生物学状态密切相关。在动态互惠的框架中，矩阵的建模和重塑是由局部细胞环境以及分泌的和与细胞相关的成分驱动的。该专家撰写的评论集旨在传递有关生理发育和疾病中矩阵建模和重塑机制的最新信息。