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A concise predictive nomogram for renal artery stenosis in selective patients undergoing coronary angiography
Journal of the American Society of Hypertension Pub Date : 2018-07-25 , DOI: 10.1016/j.jash.2018.07.004
Haojian Dong , Zhiqiang Nie , Wenhui Huang , Yuan Liu , Guang Li , Yanqiu Ou , Yingling Zhou , Jianfang Luo

As reported scoring systems of renal artery stenosis (RAS) screening were not easily validated, we further proposed a simple method to predict or rule out RAS in selective patients undergoing coronary angiography (CAG). After preliminary inclusive criterion (severe hypertension or atherosclerosis, flash pulmonary edema, or unexplained renal dysfunction), 503 and 158 consecutive patients undergoing renal arteriography at the timing of CAG were separately enrolled between 2012 and 2015, and 2016 and 2017 as the development and validation cohort. A nomogram was derived from the multivariable logistic regression model, and its accuracy was assessed by the area under the receiver operating characteristic. Hypertension (odds ratio [OR] 17.92), estimated glomerular filtration rate ≤72.66 mL/min·1.73 m2 (OR 2.75), early to late transmitral flow velocity ratio ≤1.02 (OR 2.58) and low-density lipoprotein cholesterol ≤3.17 mmol/L (OR 1.85) were identified as independent predictors for RAS. The area under the curve of the nomogram in the development and validation cohort were 0.754 (0.704, 0.804) and 0.772 (0.700, 0.844). The negative predictive value of hypertension (88.9%) was much higher than the other three predictors. The concise predictive nomogram can effectively estimate the probability of significant RAS during CAG. Along with normotensive, findings reported could easily evaluate RAS screening necessity based on clinical data.



中文翻译:

选择性冠状动脉造影患者肾动脉狭窄的简明预测列线图

由于报道的肾动脉狭窄(RAS)筛查评分系统不容易验证,我们进一步提出了一种简单的方法来预测或排除接受冠状动脉造影(CAG)的选择性患者的RAS。根据初步的纳入标准(严重高血压或动脉粥样硬化,肺部水肿或不明原因的肾功能不全),在2012年至2015年以及2016年和2017年之间分别选择了503例和158例在CAG时接受肾动脉造影的患者,作为开发和验证的依据队列。从多变量对数回归模型中得出了诺模图,并通过接收器工作特性下的面积来评估其准确性。高血压(比值[OR] 17.92),估计肾小球滤过率≤72.66mL / min·1.73 m 2(OR 2.75),早晚传输流速比≤1.02(OR 2.58)和低密度脂蛋白胆固醇≤3.17mmol / L(OR 1.85)被确定为RAS的独立预测因子。在开发和验证队列中,列线图曲线下的面积分别为0.754(0.704,0.804)和0.772(0.700,0.844)。高血压的阴性预测值(88.9%)远高于其他三个预测值。简洁的预测列线图可以有效地估计CAG期间发生重要RAS的可能性。除血压正常外,报告的发现还可以根据临床数据轻松评估RAS筛查的必要性。

更新日期:2018-07-25
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