Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

中文翻译：

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CCR5Δ32纯合干细胞同种异体移植后，已存在的CXCR4-tropic人类免疫缺陷病毒变种的快速反弹。

纯合CCR5Δ32干细胞的同种异体干细胞移植（alloSCT）曾经治愈了人类免疫缺陷病毒（HIV）感染。我们最近报道了在类似情况下的病毒式突破。在这里，我们证明了alloSCT之后的快速反弹与高度复制的CXCR4嗜性HIV变异有关，在alloSCT之前就已经可以检测到该变异。