Official control biotoxin testing of bivalve molluscs from Great Britain has been conducted by Cefas for over a decade. Reflecting the changes in legislation, bioassays were gradually replaced by analytical methods, firstly for analysis of Paralytic shellfish toxins, followed by introduction of liquid chromatography tandem mass spectrometric (LCMS/MS) method for lipophilic toxins (LTs) in 2011. Twelve compounds, representing three main groups of regulated lipophilic toxins, as well as two non-regulated cyclic imines were examined in over 20,500 samples collected between July 2011 and December 2016. The toxins belonging to Okadaic acid (OA) group toxins were the most prevalent and were quantified in 23% of samples, predominantly from Scotland. The temporal pattern of OA group occurrences remained similar each year, peaking in summer months and tailing off during autumn and winter, however their abundance and magnitude varied between years significantly, with concentrations reaching up to 4993 μg OA eq./kg.

Three toxin profiles were identified, reflecting the relative contribution of the two main toxins, OA and dinophysis toxin-2 (DTX2). Dinophysis toxin-1 (DTX1) was less common and was never detected in samples with high proportions of DTX2. Inter-annual changes in profiles were observed within certain regions, with the most notable being an increase of DTX2 occurrences in north-west Scotland and England in the last three years of monitoring. In addition, seasonal changes of profiles were identified when OA, the dominant toxin in early summer, was replaced by higher proportions of DTX2 in late summer and autumn. The profile distribution possibly reflected the availability of individual Dinophysis species as a food source for shellfish, however persistence of DTX2 during autumn and winter in mussels might have also been attributed to their physiology. Mussels were the only species with higher average proportions of non-esterified toxins, while Pacific oysters, cockles, surf clams, razors and queen scallops contained almost exclusively ester forms. In addition, a temporal change in proportion of OA and DTX2 free form was observed in mussels.

Pectenotoxin-2 (PTX2) was quantified only on rare occasions.

Cefas已进行了来自英国的双壳类软体动物官方对照生物毒素测试，已有十多年的历史了。为了反映法规的变化，生物测定法逐渐被分析方法所取代，首先用于分析麻痹性贝类毒素，然后引入液相色谱串联质谱法（LC）。MS / MS）方法于2011年进行了研究。在2011年7月至2016年12月收集的20,500多个样品中，对代表三种主要组的亲脂性毒素以及十二种非法规化环状亚胺的十二种化合物进行了检测。冈田酸（OA）类毒素属于最常见的毒素，在23％的样品中定量，主要来自苏格兰。OA组发生的时间模式每年保持相似，在夏季月份达到峰值，在秋季和冬季逐渐降低，但是它们的丰度和强度在不同年份之间差异很大，其浓度高达4993μgOA eq./kg。

确定了三种毒素概况，反映了两种主要毒素OA和Dinophysis毒素2（DTX2）的相对贡献。Dinophysis毒素1（DTX1）较少见，在高比例DTX2的样品中从未检出。在某些区域观察到剖面的年际变化，最显着的是在最近三年的监测中，苏格兰西北部和英格兰的DTX2发生率增加。此外，当夏季初夏的主要毒素OA被夏末和秋季晚些时候较高比例的DTX2代替时，可以确定其季节变化。剖面分布可能反映了单个恐龙的可用性物种作为贝类的食物来源，然而DTX2在贻贝在秋冬季节的持久性也可能归因于它们的生理特性。贻贝是唯一具有较高平均非酯化毒素比例的物种，而太平洋牡蛎，蛤，蛤，剃须刀和扇贝几乎只含有酯形式。另外，在贻贝中观察到OA和DTX2游离形式的比例随时间变化。

仅在极少数情况下对Pectenotoxin-2（PTX2）进行了定量。