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The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-21 Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang
ScopeBile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated.Methods and resultsThis study assesses the impact of
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Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet‐Induced Obese Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-19 Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura
ScopeObesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)‐supplemented diet may ameliorate obesity
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Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-19 Yue Li, Yuwei Lai, Tingting Geng, Peng‐Fei Xia, Jun‐Xiang Chen, Zhou‐Zheng Tu, Kun Yang, Yun‐Fei Liao, Gang Liu, An Pan
ScopeAmong patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.Methods
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High Fat Diet–Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-18 Yuri Haneishi, Lucia Treppiccione, Francesco Maurano, Diomira Luongo, Junki Miyamoto, Mauro Rossi
The intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In celiac disease (CD), the serum phospholipid profile in infants who
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Molecular Characterization of the Allergenic Arginine Kinase from the Edible Insect Hermetia illucens (Black Soldier Fly) Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-17 Danila Delfino, Barbara Prandi, Luisa Calcinai, Erminia Ridolo, Luca Dellafiora, Lorenzo Pedroni, Francesca Nicoletta, Davide Cavazzini, Tullia Tedeschi, Claudia Folli
ScopeArginine kinase (AK) is an important enzyme for energy metabolism of invertebrate cells by participating in the maintenance of constant levels of ATP. However, AK is also recognized as a major allergen in insects and crustaceans capable of cross‐reactivity with sera of patients sensitized to orthologous proteins. In the perspective of introducing insects or their derivatives in the human diet
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Front Cover: Profiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-16 Richard Ethier, Arun Krishnamurthy, Michael Jeffrey, Thomas A. Tompkins
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Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-11 Shahira M. Ezzat, Rana M. Merghany, Passent M. Abdel Baki, Nariman Ali Abdelrahim, Sohaila M. Osman, Mohamed A. Salem, Sheila I. Peña‐Corona, Hernán Cortés, Lashyn Kiyekbayeva, Gerardo Leyva‐Gómez, Javad Sharifi‐Rad, Daniela Calina
Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities
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Assessing and Comparing Potential Allergenicity of Two Partially Hydrolyzed Whey‐Based Formulas for Infants: A Population‐Based Study in China Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-11 Lijuan Sun, Shiwen Han, Sufang Duan, Like Mao, Fang Li, Zhenhua Tu, Huilian Che
ScopeIn cases where breast milk is unavailable or inadequate, hydrolyzed infant formula is recommended as the primary alternative. The aim of this study is to assess and compare the allergenicity of two partially hydrolyzed whey‐based formulas (PHF‐Ws) using serum samples from patients with cow's milk allergy (CMA).Methods and resultsLC‐MS/MS technology is used to investigate the peptide distribution
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Polyphenol Extracts from Ziziphus jujuba Mill. “Junzao” Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-11 Xiaobo Wei, Ni Ma, Wen Yang, Jinhu Tian, Huiyan Liu, Haitian Fang
ScopePolyphenols are the major active substances in red jujube fruit, and their anti‐inflammatory and antioxidant activities suggest their potential utility in the prevention of ulcerative colitis (UC).Methods and resultsIn this study, the effect of polyphenol extracts from red jujube (Ziziphus jujuba Mill. “Junzao”) (PERJ) on the dextron sulfate sodium (DSS)‐induced UC mice is investigated. The result
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Investigation of Antiproliferative Effects of Combinations of White and Black Garlic Extracts with 5‐Fluorouracil (5‐FU) on Caco‐2 Colorectal Adenocarcinoma Cells Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-11 Derya Ozalp Unal, Tevhide Sel
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Curry‐Odorants and Their Metabolites Transfer into Human Milk and Urine Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-11 Marcel W. Debong, Ines Homm, Michael Gigl, Roman Lang, Thomas Hofmann, Andrea Buettner, Corinna Dawid, Helene M. Loos
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A New Insight into Fatty Acid Binding Protein 4 Mechanisms and Therapeutic Implications in Obesity‐Associated Diseases: A Mini Review Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-09 Feyza Nur Başarır Sivri, Seda Çiftçi
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Bcat2‐Mediated Branched‐Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-06 Yazhuo Wang, Ning Zhao, Yujiao Meng, Jia Chen, Cong Qi, Xueqing Hu, Haoyue Zhu, Danyang Yang, Xiawei Zhang, Huike Ma, Jingxia Zhao, Tingting Di, Ping Li, Yan Wang
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Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non‐muscle Invasive Bladder Cancer Prognosis in the Be‐Well Study Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-06 Zinian Wang, Marilyn L. Kwan, Reina Haque, Prashant K. Singh, Maciej Goniewicz, Rachel Pratt, Valerie S. Lee, Janise M. Roh, Isaac J. Ergas, Kimberly L. Cannavale, Ronald K. Loo, David S. Aaronson, Charles P. Quesenberry, Yuesheng Zhang, Christine B. Ambrosone, Lawrence H. Kushi, Li Tang
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Naringenin Alleviates Radiation‐Induced Intestinal Injury by Inhibiting TRPV6 in Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-06 Zhi Ling, Zheng Wang, Lin Chen, Jingxian Mao, Dongmei Ma, Xiao Han, Linlin Tian, Qingtian Zhu, Guotao Lu, Xuebing Yan, Yanbing Ding, Weiming Xiao, Yong Chen, Aijun Peng, Xudong Yin
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Dietary Supplementation with Nervonic Acid Ameliorates Cerebral Ischemia‐Reperfusion Injury by Modulating of Gut Microbiota Composition‐Fecal Metabolites Interaction Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-03 Hui Zhou, Ziyi Chen, Jingbin Li, Rongjin Wang, Hongshi Bu, Chengjiang Ruan
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Maternal Brown Rice Diet during Pregnancy Promotes Adipose Tissue Browning in Offspring via Reprogramming PKA Signaling and DNA Methylation Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-04-03 Lamei Xue, Juan Sun, Yujie Sun, Yu Wang, Kuiliang Zhang, Mingcong Fan, Haifeng Qian, Yan Li, Li Wang
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Applications of Strain‐Specific Probiotics in the Management of Cardiovascular Diseases: A Systemic Review Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-29 Saleha Khan, Firdos Ahmad, Nauman Khalid
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Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-29 Arya Devi Karikkakkavil Prakashan, Serva Peddha Muthukumar, Asha Martin
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l‐Theanine Prevents Colonic Damage via NF‐κB/MAPK Signaling Pathways Induced by a High‐Fat Diet in Rats Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-29 Chunyan Fang, Yifeng Shen, Ziyang Ma, Yuchen Li, Jingyi Zhang, Chen Liu, Yulong Ye
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Protective Mechanism of Polysaccharide ORP-1 Isolated from Oudemansiella raphanipes against Age-Related Cognitive Decline through the Microbiota-Gut-Brain Axis Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-25 Yu-Ru Ren, Wen-Ting Cui, Kai-Li Jiang, Kai-Qi He, Yong-Ming Lu, Yan Chen, Wen-Juan Pan
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Profiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-24 Richard Ethier, Arun Krishnamurthy, Michael Jeffrey, Thomas A. Tompkins
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Potential Function of 3,5-Dihydroxy-4-Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-24 MinYu Chen, Min Liu, JingHong Chen, Xinwei Liu, LiWei Tang, Chao Wang, Ziniu Yu, Yang Zhang, Jing Tian
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Palmitoleic Acid Ameliorates Metabolic Disorders and Inflammation by Modulating Gut Microbiota and Serum Metabolites Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-21 Junhui Zhang, Minjie Zhao, Huilin Yu, Qianqian Wang, Fei Shen, Haiying Cai, Fengqin Feng, Jun Tang
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Relevant Aspects of Combined Protocols for Prevention of N(M)AFLD and Other Non-Communicable Diseases Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-20 Luis A. Videla, Rodrigo Valenzuela, Jessica Zúñiga-Hernández, Andrea del Campo
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Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-19 Hongkun Lin, Xiaoping Guo, Jingjing Liu, Yuhan Tang, Li Chen, Huimin Chen, Ying Zhao, Lili Wang, Hongxia Li, Jiasheng Yu, Ping Yao
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Advances in Bio-Optical Imaging Systems for Spatiotemporal Monitoring of Intestinal Bacteria Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-15 Tongtong Pan, Lihuang Su, Yiying Zhang, Liang Xu, Yongping Chen
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Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-15 Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Bao
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Effect of Single Oral Coingestion of GABA and Malic Acid on Postprandial GLP-1, Glucose, and Insulin Responses in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-15 Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hira
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Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-15 Saisree Iyer, Ishani Bhat, Mamatha Bangera Sheshappa
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Restoration of Intestinal Microbiota After Inulin Supplementation Halted: The Secondary Effect of Supplemented Inulin Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-14 Ran An, Xilong Zhou, Jing Zhang, Yaqi Yang, Chengang Lyu, Dapeng Wang
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A Probiotic Targets Bile Acids Metabolism to Alleviate Ulcerative Colitis by Reducing Conjugated Bile Acids Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-13 Fan Jingjing, Jin Weilin, Su Shaochen, Khan Aman, Wu Ying, Chen Yanyi, Feng Pengya, Jeon Byong-Hun, Salama EL-Sayed, Ling Zhenmin, Liu Pu, Li Xiangkai
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Urolithin A Ameliorates Athletic Ability and Intestinal Microbiota in Sleep Deprivation from the Perspective of the Gut-Muscle Axis Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-11 Hongkang Zhu, Haotian Zhao, He Qian, Chang Liu
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Gut Microbiota Metabolite TMA May Mediate the Effects of TMAO on Glucose and Lipid Metabolism in C57BL/6J Mice Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-08 Xiao-Yue Li, Zhu-Lin Yu, Ying-Cai Zhao, Dan-Dan Wang, Chang-Hu Xue, Tian-Tian Zhang, Yu-Ming Wang
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Docosahexaenoic Acid Modulates Nonalcoholic Fatty Liver Disease by Suppressing Endocannabinoid System Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-02 Yan-fang Chen, Ze-kai Fan, Yin-peng Wang, Peng Liu, Xiao-fei Guo, Duo Li
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Short-Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-01 Gohar Azhar, Ambika Verma, Michael S. Robeson, Pankaj Patyal, Intawat Nookaew, Shakshi Sharma, Amanda Pangle, Yingni Che, Robert R. Wolfe, Jeanne Y. Wei
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L-Citrulline Ameliorates Iron Metabolism and Mitochondrial Quality Control via Activating AMPK Pathway in Intestine and Improves Microbiota in Mice with Iron Overload Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-03-01 Dai Zhao, Yuan Gao, Yiqin Chen, Yingsi Zhang, Yian Deng, Sai Niu, Hanchuan Dai
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Front Cover: Gastro‐Intestinal Digested Bovine Milk Osteopontin Modulates Gut Barrier Biomarkers In Vitro Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-29 Lu Li, Juchun Chen, Yuxing Zheng, Jonathan Lane, Ruibiao Hu, Jianzhong Zhu, Xiong Fu, Qiang Huang, Feitong Liu, Bin Zhang
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Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-28 Shuli Man, Jingxian Bi, Furui Liu, Wenwen Xie, Long Ma
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Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-25 Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza-Mello, Julio Beltrame Daleprane
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Hypolipidemic and Anti-Obesity Effect of Anserine on Mice Orally Administered with High-Fat Diet via Regulating SREBP-1, NLRP3, and UCP-1 Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-24 Jing Luo, Ming Chen, Hongwu Ji, Weifeng Su, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu
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Metabolomic Investigation of Brain and Liver in Rats Fed Docosahexaenoic Acid in Regio- and Enantiopure Triacylglycerols Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-23 Raghunath Pariyani, Yumei Zhang, Gudmundur G. Haraldsson, Kang Chen, Kaisa M. Linderborg, Baoru Yang
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Effect of l‐Carnitine Supplementation on Osteoarthritis: A Systematic Review Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-23 Haiyang Kou, Bo Li, Zhili Wang, Jianbing Ma
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Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-23 Xingwen Yang, Shiwei Yao, Qihong Jiang, Hui Chen, Shulai Liu, Guoxin Shen, Xingwei Xiang, Lin Chen
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A Gently Processed Skim Milk-Derived Whey Protein Concentrate for Infant Formula: Effects on Gut Development and Immunity in Preterm Pigs Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Karoline Aasmul-Olsen, Halise Gül Akıllıoğlu, Line Iadsatian Christiansen, Kasper Engholm-Keller, Anders Brunse, Denitsa Vladimirova Stefanova, Ann Bjørnshave, Mie Rostved Bechshøft, Kerstin Skovgaard, Thomas Thymann, Per Torp Sangild, Marianne Nissen Lund, Stine Brandt Bering
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Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Lucas Keuter, Alessa Wolbeck, Matthias Kasimir, Lina Schürmann, Matthias Behrens, Hans-Ulrich Humpf
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Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Ramya Jayaprakash, Chris Pook, Farha Ramzan, Jennifer L. Miles-Chan, Richard F. Mithen, Meika Foster
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Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Chia-Yuan Lin, Nam Nhat Nguyen, Wan-Ling Tsai, Rong-Hong Hsieh, Hung-Tsung Wu, Yang-Ching Chen
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Astragaloside IV Mitigated Diabetic Nephropathy by Restructuring Intestinal Microflora and Ferroptosis Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Xin Lyu, Ting-ting Zhang, Zhen Ye, Ce Chen
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Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-22 Ghulam Shere Raza, Yağmur Kaya, Ville Stenbäck, Ravikant Sharma, Nalini Sodum, Shivaprakash Jagalur Mutt, Dominique D. Gagnon, Mikko Tulppo, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Kari A. Mäkelä
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Novel Targets and Potential Mechanisms of Mizuhopecten yessoensis-Derived Tripeptide NCW as Antihypertensive Peptides Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-17 Sijia Wu, Wenzhu Zhao, Zhipeng Yu
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Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-17 Lili Qiu, Mengxiao Hu, Xiyu Qin, Rui Song, Yanan Sun, Xiaoyu Wang
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Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-17 Jie Liang, Ting Chen, Honglei Xu, Tingfang Wang, Qi Gong, Tingting Li, Xiaoyan Liu, Jing Wang, Yun Wang, Liyan Xiong
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Syringaresinol Alleviates Early Diabetic Retinopathy by Downregulating HIF-1α/VEGF via Activating Nrf2 Antioxidant Pathway Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-14 Chang Liu, Tianwei Cheng, Yufei Wang, Guangru Li, Yachen Wang, Wencong Tian, Lifeng Feng, Shengzheng Zhang, Yang Xu, Yang Gao, Jing Li, Jie Liu, Jianlin Cui, Jie Yan, Lei Cao, Zhongjie Pan, Zhi Qi, Liang Yang
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Chicken Muscle-Derived ACE2-Upregulating Peptide VVHPKESF Reduces Blood Pressure Associated with the ACE2/Ang (1-7)/MasR Axis in Spontaneously Hypertensive Rats Mol. Nutr. Food Res. (IF 5.2) Pub Date : 2024-02-14 Hongbing Fan, Nan Shang, Sandra T. Davidge, Jianping Wu