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Synthetic Biology: Immunotherapy by Design
Annual Review of Biomedical Engineering ( IF 9.7 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1146/annurev-bioeng-062117-121147
Jamie Brenner 1 , Jang Hwan Cho 1 , Nicole M L Wong 1 , Wilson W Wong 1
Affiliation  

Cellular immunotherapy holds great promise for the treatment of human disease. Clinical evidence suggests that T cell immunotherapies have the potential to combat cancers that evade traditional immunotherapy. Despite promising results, adverse effects leading to fatalities have left scientists seeking tighter control over these therapies, which is reflected in the growing body of synthetic biology literature focused on developing tightly controlled, context-independent parts. In addition, researchers are adapting these tools for other uses, such as for the treatment of autoimmune disease, HIV infection, and fungal interactions. We review this body of work and devote special attention to approaches that may lend themselves to the development of an “ideal” therapy: one that is safe, efficient, and easy to manufacture. We conclude with a look toward the future of immunotherapy: how synthetic biology can shift the paradigm from the treatment of disease to a focus on wellness and human health as a whole.

中文翻译:


合成生物学:设计免疫疗法

细胞免疫疗法对治疗人类疾病具有很大的前景。临床证据表明,T 细胞免疫疗法有可能对抗逃避传统免疫疗法的癌症。尽管取得了可喜的结果,但导致死亡的不良反应使科学家们寻求对这些疗法进行更严格的控制,这反映在越来越多的合成生物学文献中,这些文献专注于开发严格控制的、与上下文无关的部分。此外,研究人员正在将这些工具用于其他用途,例如用于治疗自身免疫性疾病、艾滋病毒感染和真菌相互作用。我们回顾了这项工作,并特别关注可能有助于开发“理想”疗法的方法:一种安全、高效且易于制造的方法。

更新日期:2018-06-04
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