Annual Review of Biomedical Engineering ( IF 9.7 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1146/annurev-bioeng-062117-121019 Josef R. Bober 1 , Chase L. Beisel 2 , Nikhil U. Nair 1
An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.
中文翻译:
合成生物学方法为生物医学应用设计益生菌和人类微生物群的成员。
越来越多的研究已将人类微生物群的组成与许多人类健康状况紧密相关,并且在某些情况下,已表明操纵微生物群直接影响健康。这些见识引起了人们对工程化土著微生物群落成员和非居民益生菌作为能够诊断和改善人类健康的生物诊断和治疗方法的极大兴趣。在这篇综述中,我们将讨论合成生物学的最新进展,以针对这些目的设计共生和益生菌乳酸菌,双歧杆菌和拟杆菌,并就这些技术的未来潜力提供观点。