This review aims to provide a comprehensive overview about various innovative strategies that have been employed by recent researchers to overcome with the shortcomings associated with traditional microspheres. Essentially, optimization strategies from structural aspects have been widely investigated to improve the properties (e.g., enhanced hydrophilicity, reduced initial burst release, etc.) of the pristine microspheres. These include bulk alteration, surface modification as well as the formation of sophisticated microsphere design such as core-shell structures. Other than that, various microencapsulation techniques and novel technologies such as spray drying, supercritical fluid technique, membrane, and microfluidics emulsification also have been explored in this review. Additionally, the impact of formulation-related aspects on the drug encapsulation efficiency, particles size and particles size distribution during double emulsification method will also be discussed and reviewed extensively based on the recent literatures reported.

中文翻译：

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提高可生物降解的PLA / PLGA微球治疗功效的方法：综述

这篇综述旨在提供有关各种创新策略的全面概述，这些创新策略已被最近的研究人员用来克服与传统微球相关的缺点。实质上，已经广泛研究了结构方面的优化策略以改善性能（例如，增强亲水性，减少初始突释等）。）的原始微球。这些包括整体改变，表面改性以及复杂的微球设计（如核-壳结构）的形成。除此之外，本文还探讨了各种微囊化技术和新颖技术，例如喷雾干燥，超临界流体技术，膜和微流体乳化。另外，还将基于最近报道的文献广泛讨论和审查与制剂相关的方面对双重乳化方法期间药物包封效率，粒径和粒径分布的影响。