Introduction: Deep brain stimulation (DBS) markedly improves motor function in advanced Parkinson’s disease (PD), but its effect on sleep is less clear. Patients and methods: Forty PD patients who had subthalamic DBS (STN-DBS) were identified from an on-going non-motor naturalistic longitudinal study (NILS). All patients were followed up for at least 6 months, 26 patients had a 1 year follow-up. A total PDSS score of 100 or less, a score in any PDSS-item of 6 or less, and a Epworth score of 10 or more were classified as being significant. Results: Forty-five percent of patients reported significant improvement in the total PDSS score at 6 months, and 35% at 12 months. In terms of magnitude, the total PDSS score at 6 months was significantly improved from baseline while the improvement at 12 months was not statistically significant. The most frequently reported improvements were overall sleep quality and maintenance of sleep. Some patients reported worsening of the total PDSS score. More than half of the patients reporting daytime sleepiness at baseline had persistent sleepiness at 6 and 12 months. The mean Epworth Score did not improve because a significant number of patients without sleepiness at baseline reported new-onset sleepiness at 6 and 12 months. Neither medication changes nor motor improvement were consistently related to sleep changes after DBS. Conclusion: Subthalamic DBS is associated with a statistically and clinically significant, but variable, improvement in sleep as measured by the PDSS. The most frequent improvements were better overall sleep quality and better sleep maintenance.

简介：深部脑刺激（DBS）可以显着改善晚期帕金森病（PD）的运动功能，但对睡眠的影响尚不清楚。患者和方法：从正在进行的非运动自然纵向研究（NILS）中识别出40位患有丘脑底DBS（STN-DBS）的PD患者。所有患者均接受了至少6个月的随访，其中26例接受了1年的随访。PDSS的总分不超过100，任何PDSS项的得分不超过6，以及Epworth的得分不超过10，均被视为具有重大意义。结果：45％的患者在6个月时报告的PDSS总评分有显着改善，在12个月时报告了35％的患者。就幅度而言，第6个月的PDSS总评分较基线有明显改善，而第12个月的改善无统计学意义。最常报告的改善是总体睡眠质量和睡眠维持。一些患者报告总PDSS评分恶化。基线时报告白天嗜睡的患者中，超过一半的患者在6和12个月时持续嗜睡。由于大量患者，平均Epworth得分并未改善基线无嗜睡的患者在6和12个月时报告新发作的嗜睡。DBS后，药物改变和运动改善均与睡眠改变无关。结论：丘脑底DBS与通过PDSS测量的具有统计学和临床​​意义但可变的睡眠改善相关。最频繁的改进是改善整体睡眠质量和改善睡眠维持。