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Modeling Cell Size Regulation: From Single-Cell-Level Statistics to Molecular Mechanisms and Population-Level Effects
Annual Review of Biophysics ( IF 12.4 ) Pub Date : 2018-05-24 00:00:00 , DOI: 10.1146/annurev-biophys-070317-032955
Po-Yi Ho 1 , Jie Lin 1 , Ariel Amir 1
Affiliation  

Most microorganisms regulate their cell size. In this article, we review some of the mathematical formulations of the problem of cell size regulation. We focus on coarse-grained stochastic models and the statistics that they generate. We review the biologically relevant insights obtained from these models. We then describe cell cycle regulation and its molecular implementations, protein number regulation, and population growth, all in relation to size regulation. Finally, we discuss several future directions for developing understanding beyond phenomenological models of cell size regulation.

中文翻译:


模拟细胞大小调控:从单细胞水平统计到分子机制和种群水平效应

大多数微生物调节其细胞大小。在本文中,我们回顾了细胞大小调节问题的一些数学公式。我们专注于粗粒度随机模型及其生成的统计数据。我们回顾了从这些模型获得的生物学相关的见解。然后,我们描述细胞周期调控及其分子实施,蛋白质数量调控和种群增长,所有这些都与尺寸调控有关。最后,我们讨论了发展超越细胞大小调控的现象学模型的理解的几个未来方向。

更新日期:2018-05-24
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