Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.

中文翻译：

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鼠类Ib MHC在自然杀伤细胞的发育和激活中的扩展作用。

主要的组织相容性复合物-I（MHC-1）分子可分为Ia类和Ib类，在小鼠中发现了三个不同的Ib类家族。这些家族被命名为Q，T和M，并且就其免疫功能而言在很大程度上尚未被开发。在Ib类MHC中，由于H2-T23（Qa-1b）与人Ib类人白细胞抗原（HLA）-E具有同源性，因此H2-T23（Qa-1b）已成为自然杀伤（NK）细胞研究的重要目标。但是，最近的数据表明，Ib MHC类Q和M家族成员在NK细胞的发育和调节中也起着关键作用。在这里，我们讨论了通过鼠类Ib MHC控制NK细胞的最新进展，以此作为刺激进一步探索这些分子的手段。