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Sensing Chirality with Rotational Spectroscopy
Annual Review of Physical Chemistry ( IF 14.7 ) Pub Date : 2018-04-20 00:00:00 , DOI: 10.1146/annurev-physchem-052516-050629
Sérgio R. Domingos 1, 2, 3 , Cristóbal Pérez 1, 2, 3 , Melanie Schnell 1, 2, 3
Affiliation  

Chiroptical spectroscopy techniques for the differentiation of enantiomers in the condensed phase are based on an established paradigm that relies on symmetry breaking using circularly polarized light. We review a novel approach for the study of chiral molecules in the gas phase using broadband rotational spectroscopy, namely microwave three-wave mixing, which is a coherent, nonlinear, and resonant process. This technique can be used to generate a coherent molecular rotational signal that can be detected in a manner similar to that in conventional Fourier transform microwave spectroscopy. The structure (and thermal distribution of conformations), handedness, and enantiomeric excess of gas-phase samples can be determined unambiguously by employing tailored microwave fields. We discuss the theoretical and experimental aspects of the method, the significance of the first demonstrations of the technique for enantiomer differentiation, and the method's rapid advance into a robust choice to study molecular chirality in the gas phase. Very recently, the microwave three-wave mixing approach was extended to enantiomer-selective population transfer, an important step toward spatial enantiomer separation on the fly.

中文翻译:


旋转光谱传感手性

用于在冷凝相中区分对映异构体的手性光谱技术基于建立的范例,该范例依赖于使用圆偏振光的对称性破坏。我们回顾了一种使用宽带旋转光谱技术研究气相中手性分子的新方法,即微波三波混合,这是一个相干,非线性和共振的过程。该技术可用于产生相干分子旋转信号,该信号可以以与常规傅立叶变换微波光谱法类似的方式检测。气相样品的结构(和构象的热分布),手性和对映体过量可以通过采用定制的微波场来明确确定。我们讨论了该方法的理论和实验方面,首次证明该技术对映异构体分化的意义,以及该方法的快速发展,成为研究气相中分子手性的可靠选择。最近,微波三波混合方法已扩展到对映异构体选择性种群转移,这是朝着飞行中空间对映异构体分离迈出的重要一步。

更新日期:2018-04-20
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