The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system. Trafficking of mGlu receptors in and out of the synaptic plasma membrane is a fundamental mechanism modulating excitatory synaptic function through regulation of receptor abundance, desensitization, and signaling profiles. In this review, we cover the regulatory mechanisms determining surface expression and endocytosis of mGlu receptors, with particular focus on post-translational modifications and receptor-protein interactions. The literature we review broadens our insight into the precise events defining the expression of functional mGlu receptors at synapses, and will likely contribute to the successful development of novel therapeutic targets for a variety of developmental, neurological, and psychiatric disorders.

代谢型谷氨酸受体（mGlu受体）是G蛋白偶联受体，与兴奋性神经递质谷氨酸结合，在调节神经元兴奋性，突触传递和中枢神经系统的可塑性中起重要作用。mGlu受体进出突触质膜的运输是通过调节受体丰度，脱敏和信号传导分布来调节兴奋性突触功能的基本机制。在这篇综述中，我们涵盖了确定mGlu受体的表面表达和内吞作用的调节机制，特别着重于翻译后修饰和受体-蛋白质相互作用。我们回顾的文献拓宽了我们对定义突触中功能性mGlu受体表达的精确事件的认识，