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DNA methylation signatures of educational attainment
npj Science of Learning ( IF 4.2 ) Pub Date : 2018-03-23 , DOI: 10.1038/s41539-018-0020-2
Jenny van Dongen , , Marc Jan Bonder , Koen F. Dekkers , Michel G. Nivard , Maarten van Iterson , Gonneke Willemsen , Marian Beekman , Ashley van der Spek , Joyce B. J. van Meurs , Lude Franke , Bastiaan T. Heijmans , Cornelia M. van Duijn , P. Eline Slagboom , Dorret I. Boomsma

Educational attainment is a key behavioural measure in studies of cognitive and physical health, and socioeconomic status. We measured DNA methylation at 410,746 CpGs (N = 4152) and identified 58 CpGs associated with educational attainment at loci characterized by pleiotropic functions shared with neuronal, immune and developmental processes. Associations overlapped with those for smoking behaviour, but remained after accounting for smoking at many CpGs: Effect sizes were on average 28% smaller and genome-wide significant at 11 CpGs after adjusting for smoking and were 62% smaller in never smokers. We examined sources and biological implications of education-related methylation differences, demonstrating correlations with maternal prenatal folate, smoking and air pollution signatures, and associations with gene expression in cis, dynamic methylation in foetal brain, and correlations between blood and brain. Our findings show that the methylome of lower-educated people resembles that of smokers beyond effects of their own smoking behaviour and shows traces of various other exposures.



中文翻译:

受教育程度的DNA甲基化特征

受教育程度是认知和身体健康以及社会经济状况研究中的关键行为指标。我们在410,746 CpGs(N = 4152),并确定了58个与基因位点的教育程度相关的CpG,其特征是多效性功能与神经元,免疫和发育过程共有。与吸烟行为的相关性重叠,但在考虑了许多CpGs的吸烟后仍然存在:调整吸烟后,效应大小平均降低28%,在11 CpGs时基因组范围内显着,在从未吸烟者中降低62%。我们检查了与教育相关的甲基化差异的来源和生物学含义,证明了与产前产妇叶酸,吸烟和空气污染特征的相关性,以及与顺式基因表达,胎儿脑中动态甲基化以及血液与脑部之间的相关性。

更新日期:2018-03-23
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