Fatigue is a commonly reported sequela following an acquired brain injury (ABI), and can have a negative impact on many areas of a child’s life. However, there is minimal research that focuses on fatigue specifically, and so factors such as its occurrence, duration, and impact on functioning remain uncertain. This systematic review aims to provide a comprehensive summary of the research to date, bringing together a number of studies with a focus on paediatric ABI and fatigue. Terms were searched in relevant databases (PsycInfo, Medline, CINAHL), and articles were included or excluded based on specified criteria. Of the 1177 papers identified in the original search, a total of 9 papers met inclusion criteria, and were categorised as traumatic brain injury (TBI; n = 4), meningitis and meningococcal disease (n = 2), brain tumours (n = 2), and mixed ABI group (n = 1). Key findings suggest that fatigue is a problem encountered by a significant proportion of patients in all the studies reviewed, and often occurred regardless of the cause; fatigue was also associated with poor academic achievement, limited physical activity, and social and emotional problems. Injuries of greater severity were associated with higher levels of fatigue and worse outcomes. Several management options were suggested, though their efficacy was not reported. Future research is required with a suggested focus on using multiple time points to better understand the trajectories of fatigue following childhood ABI, and to build an evidence base to determine which management options are most suitable.

中文翻译：

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小儿获得性脑损伤后的疲劳及其对功能结果的影响：系统评价

疲劳是后天性脑损伤（ABI）的普遍报道的后遗症，会对孩子的生活的许多领域产生负面影响。但是，很少有研究专门针对疲劳，因此诸如疲劳的发生，持续时间以及对功能的影响等因素仍然不确定。这篇系统的综述旨在提供迄今为止的研究的全面总结，将许多针对小儿ABI和疲劳的研究汇总在一起。在相关数据库（PsycInfo，Medline，CINAHL）中搜索术语，并根据指定的标准包括或排除文章。在最初的检索中确定的1177篇论文中，共有9篇符合纳入标准的论文被分类为脑外伤（TBI; n  = 4），脑膜炎和脑膜炎球菌病（n  = 2），脑瘤（n = 2）和混合ABI组（n  = 1）。主要发现表明，在所有审查的研究中，疲劳是相当一部分患者遇到的一个问题，并且无论原因如何，该问题经常发生。疲劳还与学习成绩差，体育活动受限以及社交和情感问题有关。严重程度更高的损伤与更高水平的疲劳和更差的结果相关。尽管尚未报告其疗效，但提出了几种管理选择。需要进行进一步的研究，建议将重点放在使用多个时间点上，以更好地理解儿童ABI后的疲劳轨迹，并建立证据基础来确定最合适的管理方案。