Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane surface. In our strategy, CMBA was firstly grafted on the PSf membrane surface through the Friedel-Crafts alkylation reaction, and the product was named BAPSf membrane. Then, SHPCS was grafted onto the BAPSf membrane surface by esterification, and the product was named SHPCS-BAPSf membrane. The effects of temperature and reaction time on the productivity of BAPSf and the grafting density of carboxyl and the effects of reaction time on the grafting density of SHPCS grafted onto the BAPSf membrane surface were studied. The SHPCS-BAPSf membranes are investigated by ATR-FTIR, XPS, contact angle measurements and evaluated by blood compatibility in vitro. The results reveal that the hydrophilicity of SHPCS-BAPSf membranes were grealy improved and the evaluation of protein adsorption, hemolysis test, platelet adhesion plasma recalcification time(PRT), activated partial thromboplastin time(APTT), prothrombin time(PT) and thrombin time(TT) confirmed that the SHPCS-BAPSf membranes have remarkable blood compatibility.

中文翻译：

---

改性聚砜膜与4-（氯甲基）苯甲酸和磺化羟丙基壳聚糖的血液相容性。

聚砜（PSf）膜广泛用于血液净化领域，但PSf膜的血液相容性不足。为了提高PSf膜的血液相容性，将4-（氯甲基）苯甲酸（CMBA）和磺化羟丙基壳聚糖（SHPCS）接枝到PSf膜表面。在我们的策略中，首先通过Friedel-Crafts烷基化反应将CMBA接枝到PSf膜表面，并将该产品命名为BAPSf膜。然后，通过酯化将SHPCS接枝到BAPSf膜表面，并将该产物命名为SHPCS-BAPSf膜。研究了温度和反应时间对BAPSf产率和羧基接枝密度的影响，以及反应时间对接枝到BAPSf膜表面的SHPCS接枝密度的影响。SHPCS-BAPSf膜通过ATR-FTIR，XPS，接触角测量进行研究，并通过体外血液相容性进行评估。结果表明，SHPCS-BAPSf膜的亲水性得到了显着改善，并评估了蛋白质吸附，溶血试验，血小板粘附血浆重钙化时间（PRT），活化部分凝血活酶时间（APTT），凝血酶原时间（PT）和凝血酶时间（ TT）确认SHPCS-BAPSf膜具有出色的血液相容性。