A novel microporous metal-organic framework (MOF) based on Zn(II) ion as node with the chemical formula of {[Zn(H₂O)(HL)]·(DMF)₂(H₂O)₂}_n (1, H₃L = 2-(4-carboxyphenyl)-1H-benzo[d]imidazole-5-carboxylic acid, DMF = N,N-dimethylformamide), which has rich water-coordinated metal centers and high density of free N-donor groups has been successfully prepared via H₃L ligand and Zn(NO₃)₂·6H₂O reaction within H₂O, EtOH along with DMF mixed solvent. The presence of open metal sites along with the basic N-donor sites in the resulting activated 1a induces a moderate high sorption capacity of CO₂. In addition, because of basic N-donor groups along with Lewis acidic Zn²⁺ ions, 1a has become an efficient heterogeneous catalyst, which can chemically fix CO₂ in the carbonate of cyclic annular at mild room temperature. Furthermore, the influence of compound on the activation of PI3K/AKT signaling pathway was studied by Western blot. The ELISA was carried out the evaluate the IL-18 and IL-6 content in synovial cells after compound treatment.

一种新型的基于Zn（II）离子的微孔金属有机骨架（MOF），化学式为{[Zn（H ₂ O）（HL）]·（DMF）₂（H ₂ O）₂ } _n（1，H ₃ L = 2-（4-羧基苯基）-1 H-苯并[ d ]咪唑-5-羧酸，DMF = N，N-二甲基甲酰胺），具有丰富的水配位金属中心和高密度的游离态N-供体基团已经有过孔H被成功地制备₃大号配体和Zn（NO ₃）₂ ·6H ₂ öH内反应₂O，EtOH和DMF混合溶剂。所得活化的1a中存在开放的金属位点以及碱性N-供体位点，会引起中等程度的CO ₂吸附能力。此外，由于碱性N供体基团以及路易斯酸性Zn ²⁺离子，1a已成为一种有效的多相催化剂，可以在温和的室温下将CO ₂化学固定在环状环状碳酸酯中。此外，通过蛋白质印迹研究了化合物对PI3K / AKT信号传导途径的激活的影响。进行ELISA处理以评估化合物处理后滑膜细胞中IL-18和IL-6的含量。