BACKGROUND Depression is common among people with schizophrenia and associated with severe positive and negative symptoms, higher rates of disability, treatment resistance and mortality related to suicide, physical and drug-related causes. However, to our knowledge, no study has been conducted to report the magnitude of depression among people with schizophrenia in Ethiopia. Therefore, this study aimed to determine the prevalence and associated factors of depression among people with schizophrenia. METHOD A hospital-based cross-sectional study was conducted among 418 patients with schizophrenia selected by systematic sampling technique. Patient Health Questionnaire 9 (PHQ-9) was used to measure depression among the study participants. To identify the potential contributing factors, we performed binary and multivariable logistic regression analysis adjusting the model for the potential confounding factors. Odds ratios (OR) with the corresponding 95% confidence interval (95%CI)) was determined to evaluate the strength of association. RESULT The prevalence estimate of depression among people with schizophrenia was found to be 18.0% [95% confidence interval: 14.50-22.30]. Our multivariable analysis revealed that current substance use (AOR 2.28, 95%CI (1.27, 4.09), suicide attempt (AOR 5.24, 95%CI (2.56, 10.72), duration of illness between 6 and 10 years (AOR 2.09, 95%CI (1.08, 4.04) and poor quality of life (AOR 3.13, 95%CI (1.79, 5.76) were found to be the factors associated with depression among people with schizophrenia. CONCLUSION The current study revealed that comorbid depression was high among people with schizophrenia and associated with current substance use, suicide attempt, and long duration of the illness as well as poor quality of life. Attention needs to be given to address comorbid depression among people with schizophrenia.

中文翻译：

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埃塞俄比亚亚的斯亚贝巴的精神分裂症患者的抑郁症患病率及相关因素，横断面研究。

背景技术抑郁症在精神分裂症患者中很常见，并伴有严重的阳性和阴性症状，更高的残疾率，治疗抵抗性以及与自杀，身体和药物相关原因相关的死亡率。然而，据我们所知，尚未进行任何研究来报告埃塞俄比亚精神分裂症患者的抑郁程度。因此，本研究旨在确定精神分裂症患者的抑郁症患病率及其相关因素。方法采用系统抽样技术，对418例精神分裂症患者进行了以医院为基础的横断面研究。患者健康问卷9（PHQ-9）用于测量研究参与者的抑郁状况。为了确定潜在的促成因素，我们进行了二元和多变量logistic回归分析，针对潜在的混杂因素调整了模型。确定具有相应95％置信区间（95％CI）的几率（OR），以评估关联强度。结果发现精神分裂症患者的抑郁症患病率估计为18.0％[95％置信区间：14.50-22.30]。我们的多变量分析显示，目前的药物使用情况（AOR 2.28，95％CI（1.27，4.09），自杀未遂（AOR 5.24，95％CI（2.56，10.72），病程在6至10年之间（AOR 2.09，95％） CI（1.08，4.04）和不良的生活质量（AOR 3.13，95％CI（1.79，5.76）被发现是精神分裂症患者抑郁症的相关因素。结论当前的研究表明，精神分裂症患者的合并抑郁症高发，并且与目前的药物滥用，自杀未遂，疾病持续时间长以及生活质量低下有关。需要注意解决精神分裂症患者的合并症抑郁症。