Journal of Neuro-Oncology ( IF 3.9 ) Pub Date : 2020-01-02 , DOI: 10.1007/s11060-019-03366-x E Guazzo 1, 2 , B Panizza 1, 2, 3
Introduction
This article provides an overview of the natural history and management of adenoid cystic carcinoma infiltrating the skull base (SB ACC).
Methods
A comprehensive review of the available literature and discussion regarding the current management of SB ACC.
Results
This review describes the unique pathology, appropriate diagnostic work-up and contemporary management options in SB ACC. There is a specific focus on the role of surgical resection with post-operative radiotherapy, given the literature suggesting a superior locoregional control rate. The importance of surgical decision making and varying surgical approaches are detailed. In addition, the emerging role of biological agents is discussed.
Conclusion
The gold standard for SB ACC is surgical resection and post-operative radiation, given the superior locoregional control. In patients not amendable to surgery, palliative radiation should be considered. The role of biological agents is still evolving. The complexity of SB ACC management mandates experienced multi-speciality management.
中文翻译:
浸润颅底的晚期腺样囊性癌的治疗:当代评论。
介绍
本文概述了浸润颅底的腺样囊性癌 (SB ACC) 的自然病程和治疗。
方法
对有关 SB ACC 当前管理的现有文献和讨论的全面审查。
结果
本综述描述了 SB ACC 的独特病理学、适当的诊断检查和现代管理选择。鉴于文献表明具有优越的局部控制率,因此特别关注手术切除和术后放疗的作用。详细介绍了手术决策和不同手术方法的重要性。此外,还讨论了生物制剂的新兴作用。
结论
鉴于优越的局部控制,SB ACC 的金标准是手术切除和术后放疗。对于不能接受手术的患者,应考虑姑息性放疗。生物制剂的作用仍在不断发展。SB ACC 管理任务的复杂性要求经历多专业管理。