Prostate cancer is one of the primary causes of death around the world. As an important drug, flutamide has been used in the clinical diagnosis of prostate cancer. However, the over dosage and improper discharge of flutamide could affect the living organism. Thus, it necessary to develop the sensor for detection of flutamide with highly sensitivity. In this paper, we report the synthesis of lanthanum cobaltite decorated halloysite nanotube (LCO/HNT) nanocomposite prepared by a facile method and evaluated for selective reduction of flutamide. The as-prepared LCO/HNT nanocomposite shows the best catalytic performance towards detection of flutamide, when compared to other bare and modified electrodes. The good electrochemical performance of the LCO/HNT nanocomposite modified electrode is ascribed to abundant active sites, large specific surface area and their synergetic effects. Furthermore, the LCO/HNT modified electrode exhibits low detection limit (0.002 μM), wide working range (0.009-145 μM) and excellent selectivity with remarkable stability. Meaningfully, the developed electrochemical sensor was applied in real environmental samples with an acceptable recovery range.

中文翻译：

---

揭示钴镧修饰的埃洛石纳米管纳米复合材料的电化学性质：一种用于测定环境样品中氟他胺的先进电催化剂。

前列腺癌是全世界死亡的主要原因之一。作为一种重要的药物，氟他胺已被用于前列腺癌的临床诊断。但是，氟他胺的过量使用和不当排放可能会影响生物体。因此，需要开发具有高灵敏度的氟他胺检测传感器。在本文中，我们报告了一种用简便方法制备的镧钴修饰的埃洛石纳米管（LCO / HNT）纳米复合材料的合成方法，并对其选择性还原氟他胺进行了评估。与其他裸电极和修饰电极相比，所制备的LCO / HNT纳米复合材料显示出对氟他胺检测的最佳催化性能。LCO / HNT纳米复合修饰电极的良好电化学性能归因于丰富的活性位点，大的比表面积及其协同作用。此外，LCO / HNT修饰电极具有低检测限（0.002μM），宽工作范围（0.009-145μM）和出色的选择性，并具有出色的稳定性。有意义的是，将开发的电化学传感器应用于具有可接受回收率范围的实际环境样品中。