BACKGROUND Excessive alcohol consumption is associated with incident atrial fibrillation and adverse atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atrial fibrillation is unclear. METHODS We conducted a multicenter, prospective, open-label, randomized, controlled trial at six hospitals in Australia. Adults who consumed 10 or more standard drinks (with 1 standard drink containing approximately 12 g of pure alcohol) per week and who had paroxysmal or persistent atrial fibrillation in sinus rhythm at baseline were randomly assigned in a 1:1 ratio to either abstain from alcohol or continue their usual alcohol consumption. The two primary end points were freedom from recurrence of atrial fibrillation (after a 2-week "blanking period") and total atrial fibrillation burden (proportion of time in atrial fibrillation) during 6 months of follow-up. RESULTS Of 140 patients who underwent randomization (85% men; mean [±SD] age, 62±9 years), 70 were assigned to the abstinence group and 70 to the control group. Patients in the abstinence group reduced their alcohol intake from 16.8±7.7 to 2.1±3.7 standard drinks per week (a reduction of 87.5%), and patients in the control group reduced their alcohol intake from 16.4±6.9 to 13.2±6.5 drinks per week (a reduction of 19.5%). After a 2-week blanking period, atrial fibrillation recurred in 37 of 70 patients (53%) in the abstinence group and in 51 of 70 patients (73%) in the control group. The abstinence group had a longer period before recurrence of atrial fibrillation than the control group (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; P = 0.005). The atrial fibrillation burden over 6 months of follow-up was significantly lower in the abstinence group than in the control group (median percentage of time in atrial fibrillation, 0.5% [interquartile range, 0.0 to 3.0] vs. 1.2% [interquartile range, 0.0 to 10.3]; P = 0.01). CONCLUSIONS Abstinence from alcohol reduced arrhythmia recurrences in regular drinkers with atrial fibrillation. (Funded by the Government of Victoria Operational Infrastructure Support Program and others; Australian New Zealand Clinical Trials Registry number, ACTRN12616000256471.).

中文翻译：

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心房颤动饮酒者的戒酒行为。

背景技术过量饮酒与房颤的发生和不良的心房重构有关。但是，戒酒对房颤的二级预防的作用尚不清楚。方法我们在澳大利亚的六家医院进行了一项多中心，前瞻性，开放标签，随机对照试验。每周饮用10杯或10杯以上标准饮料（其中1杯标准饮料含约12 g纯酒精）且基线时窦性心律阵发性或持续性心房颤动的成年人，按1：1比例随机分配为戒酒或继续平时的饮酒习惯。两个主要终点是避免房颤复发（在2周的“消隐期”之后））和随访6个月内的总房颤负担（在心房颤动中所占的时间比例）。结果在接受随机分组的140例患者中（85％为男性；平均[±SD]年龄为62±9岁），禁欲组为70例，对照组为70例。禁欲组患者的酒精摄入量从每周的16.8±7.7减少到2.1±3.7标准饮料（减少87.5％），对照组患者的酒精摄入量从每周的16.4±6.9减少到每周13.2±6.5 （减少19.5％）。在两周的消隐期后，禁欲组的70例患者中有37例（53％）再次出现房颤，而对照组的70例中有51例（73％）再次出现房颤。戒酒组房颤复发之前的时间比对照组长（危险比0.55； 95％置信区间0。36至0.84；P = 0.005）。禁欲组在6个月的随访中房颤负担显着低于对照组（房颤发生时间的中位数百分比为0.5％[四分位数范围，0.0到3.0]与1.2％[四分位数范围， 0.0至10.3]； P = 0.01）。结论戒酒可减少常规饮酒者房颤的心律失常复发。（由维多利亚州政府运营基础设施支持计划和其他机构资助；澳大利亚新西兰临床试验注册号为ACTRN12616000256471。）。2％[四分位间距，0.0到10.3]；P = 0.01）。结论戒酒可减少常规饮酒者房颤的心律失常复发。（由维多利亚州政府运营基础设施支持计划和其他机构资助；澳大利亚新西兰临床试验注册号为ACTRN12616000256471。）。2％[四分位间距，0.0到10.3]；P = 0.01）。结论戒酒可减少常规饮酒者房颤的心律失常复发。（由维多利亚州政府政府运营基础设施支持计划和其他机构资助；澳大利亚新西兰临床试验注册号为ACTRN12616000256471。）。