Alcohol use disorder (AUD) is a chronic relapsing disorder, which enforces a person to compulsively seek alcohol, restricting control over alcohol intake leads to emergence of an undesired emotional state during abstinence. There are recent advances for better understanding of neurocircuitry involved in the pathophysiology of AUD. Alcohol interaction with neuronal membrane proteins results in changes in neuronal circuits. It is also linked with the potential medication and their clinical validation concerning their pharmacological targets for alcoholic abstinence. This review covers research work from the past few decades on the therapeutic advances on treatment of alcohol dependence; further detailing the fundamental neurochemical mechanisms after alcohol administration. It also covers interaction of alcohol with GABAergic, glutaminergic, dopaminergic, serotonergic and opioid systems. This review further elaborated the neurobiology of noradrenergic, cholinergic and cannabinoid systems and their interaction with AUD. Elaborative information of potential drug targets under current exploration for AUD treatment with their mechanisms are reported here along with clinical outcomes and the associated side effects.

中文翻译：

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酒精使用障碍的靶向治疗的临床前和临床报告的神经化学证据。

酒精使用障碍（AUD）是一种慢性复发性疾病，迫使人们强迫性地寻求酒精，限制对酒精摄入的控制会导致禁欲期间出现不良的情绪状态。为了更好地了解AUD的病理生理过程中涉及的神经回路，最近有一些进展。酒精与神经元膜蛋白的相互作用导致神经元回路的变化。它还与潜在的药物及其有关戒酒的药理学目标的临床验证有关。这篇综述涵盖了过去几十年有关酒精依赖治疗的研究进展的研究工作；进一步详细介绍了酒精管理后的基本神经化学机制。它还涵盖了酒精与GABA能，谷氨酰胺，多巴胺能，血清素能和阿片样物质系统。这项审查进一步阐述了去甲肾上腺素能，胆碱能和大麻素系统的神经生物学及其与澳元的相互作用。本文报道了目前正在探索的用于AUD治疗的潜在药物靶标的实验信息及其机理，以及临床结果和相关的副作用。